Anticytokine Therapies
63 Anticytokine Therapies Zuhre Tutuncu, Arthur Kavanaugh Key Points Inhibition of a single key cytokine can be effective in autoimmune and inflammatory diseases. Most patients with rheumatoid arthritis (RA) respond…
Polyarteritis Nodosa and Related Disorders
90 Polyarteritis Nodosa and Related Disorders Raashid Luqmani Key Points Polyarteritis nodosa (PAN), characterized by vasculitis of medium-sized arteries with few or no immune deposits, is relatively rare, especially in…
Clinical Features of Osteoarthritis
99 Clinical Features of Osteoarthritis Amanda E. Nelson, Joanne M. Jordan Key Points Osteoarthritis is the most common form of arthritis, typically affecting the hands, hips, knees, spine, and feet….
Treatment of Systemic Lupus Erythematosus
81 Treatment of Systemic Lupus Erythematosus George Bertsias, Antonios Fanouriakis, Dimitrios T. Boumpas Key Points The standard of care for SLE with severe, major organ involvement involves the combination of…
Hemophilic Arthropathy
119 Hemophilic Arthropathy Katherine S. Upchurch, Doreen B. Brettler Key Points Severe hemophilia, if not aggressively treated, is often complicated by recurrent hemarthrosis. Recurrent hemarthrosis causes chronic arthropathy with overlapping…
Lyme Disease
110 Lyme Disease Linda K. Bockenstedt Key Points Lyme disease is caused by infection with tick-transmitted spirochetes of the genus Borrelia burgdorferi sensu lato and has a worldwide distribution. Lyme…
Metabolic Bone Disease
101 Metabolic Bone Disease Nancy E. Lane Key Points Osteoporosis is a disease defined by low bone density and deterioration of microarchitecture, which reduces bone strength and increases fracture risk….
Prostaglandins, Leukotrienes, and Related Compounds
24 Prostaglandins, Leukotrienes, and Related Compounds Robert B. Zurier Key Points Eicosanoid biosynthesis is catalyzed by cyclooxygenases and lipoxygenases. Conversion of the endoperoxide intermediate prostaglandin H2 requires activity of specific…
Early Synovitis and Early Undifferentiated Arthritis
72 Early Synovitis and Early Undifferentiated Arthritis Annette H.M. van der Helm-van Mil, Thomas W.J. Huizinga Key Points Early synovitis refers to synovitis that is detected by physical examination; the…
