Inflammatory Myopathies

Feb 23, 2021 by in MUSCULOSKELETAL MEDICINE Comments Off on Inflammatory Myopathies

There is a large and heterogeneous group of acquired disorders that have been grouped together collectively as inflammatory muscle diseases. Common clinical diagnoses are polymyositis, dermatomyositis and inclusion body myositis….

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Myasthenic Syndromes

Feb 23, 2021 by in MUSCULOSKELETAL MEDICINE Comments Off on Myasthenic Syndromes

There have been major advances in the understanding of the underlying causes of the various myasthenic syndromes, all of which involve abnormalities related to the neuromuscular junction ( Fig. 21.1…

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Ion Channel Disorders

Feb 23, 2021 by in MUSCULOSKELETAL MEDICINE Comments Off on Ion Channel Disorders

Action potentials in muscle, initiated by depolarization by a nerve impulse and depolarization of the muscle fibre, require the rapid movement of inorganic ions through transmembrane ion channels. The action…

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Muscular Dystrophies and Allied Disorders V: Facioscapulohumeral, Myotonic and Oculopharyngeal Muscular Dystrophies

Feb 23, 2021 by in MUSCULOSKELETAL MEDICINE Comments Off on Muscular Dystrophies and Allied Disorders V: Facioscapulohumeral, Myotonic and Oculopharyngeal Muscular Dystrophies

Facioscapulohumeral muscular dystrophy, myotonic muscular dystrophy and oculopharyngeal muscular dystrophy are dominantly inherited disorders, all of which have an unusual molecular defect involving nucleotide repeats. Clinically, facial weakness is a…

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