Skeletal Malignancies and Related Disorders

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Skeletal Malignancies and Related Disorders

Introduction One of the challenges of pediatric rheumatology is the broad spectrum of conditions ranging from the benign to the potentially life-limiting childhood malignancies that may present with relatively nonspecific…

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Noninflammatory Musculoskeletal Pain

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Noninflammatory Musculoskeletal Pain

Musculoskeletal pain of noninflammatory origin is common in childhood and is a frequent cause of referral to pediatric rheumatologists, orthopedic surgeons, sports medicine specialists, and primary care physicians. Noninflammatory causes…

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Primary Disorders of Connective Tissue

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Primary Disorders of Connective Tissue

Introduction Primary disorders of connective tissue encompass a diverse range of single gene disorders that alter the function of connective tissue cells and their extracellular matrices. The mutations have major…

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Infectious Arthritis and Osteomyelitis

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Infectious Arthritis and Osteomyelitis

Musculoskeletal infection can be considered a medical emergency, and as such it is critically important for rheumatologists to make a diagnosis quickly. Accurate diagnosis is essential to successful treatment, which…

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Musculoskeletal Manifestations of Systemic Disease

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Musculoskeletal Manifestations of Systemic Disease

Many nonrheumatic systemic disorders cause musculoskeletal signs or symptoms, most commonly arthralgia, arthritis, myalgia, or bone pain. Sometimes these are trivial; however, occasionally they are the presentations of the underlying…

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Pharmacology: Biologics

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Pharmacology: Biologics

Biologics are different from nonbiologic disease-modifying antirheumatic drugs (DMARDs) in that they are produced by biologic processes rather than chemical syntheses and target specific, well-defined molecules expressed on cells or…

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Kawasaki Disease

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Kawasaki Disease

Historical Background Kawasaki disease (KD) is one of the most common vasculitides of childhood. It has the potential to cause severe complications, significant morbidity, and even mortality. Expeditious treatment can…

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Antineutrophil Cytoplasmic Antibody Associated Vasculitis

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Antineutrophil Cytoplasmic Antibody Associated Vasculitis

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of vasculitides characterized by small- to medium-sized blood vessel inflammation, clinically overlapping features, and the presence of ANCA. This group of…

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Other Vasculitis

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Other Vasculitis

Cogan Syndrome Cogan syndrome was first described in 1945 by Dr. David Cogan, an ophthalmologist, who described four patients who developed near simultaneously interstitial keratitis and vestibular-auditory symptoms, which led…

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