RHEUMATOLOGY

Endothelial Function and its Implications for Cardiovascular and Renal Disease in Systemic Lupus Erythematosus

Oct 1, 2017 by in RHEUMATOLOGY Comments Off on Endothelial Function and its Implications for Cardiovascular and Renal Disease in Systemic Lupus Erythematosus

Vascular manifestations associated with systemic lupus erythematosus (SLE) span a broad range, including vasculopathy. An understudied pathway of this morbidity is a repair component. Recent studies have elevated the anti-injury…

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Glutamate Receptor Biology and its Clinical Significance in Neuropsychiatric Systemic Lupus Erythematosus

Oct 1, 2017 by in RHEUMATOLOGY Comments Off on Glutamate Receptor Biology and its Clinical Significance in Neuropsychiatric Systemic Lupus Erythematosus

The recent appreciation that a subset of anti-DNA antibodies cross-reacts with the N -methyl-d-aspartate receptor encourages a renewed examination of antibrain reactivity in systemic lupus erythematosus (SLE) autoantibodies. Moreover, investigations…

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Biomarkers in Lupus Nephritis

Oct 1, 2017 by in RHEUMATOLOGY Comments Off on Biomarkers in Lupus Nephritis

Biomarkers have the potential to be useful tools for noninvasively evaluating and managing patients with lupus nephritis. Many candidate biomarkers have been identified, but they require validation in larger cohorts….

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Gonadal Failure with Cyclophosphamide Therapy for Lupus Nephritis: Advances in Fertility Preservation

Oct 1, 2017 by in RHEUMATOLOGY Comments Off on Gonadal Failure with Cyclophosphamide Therapy for Lupus Nephritis: Advances in Fertility Preservation

Intravenous cyclophosphamide remains an important therapy for patients with severe systemic lupus erythematosus—including lupus nephritis, which primarily affects women in their reproductive years. As prognosis improves, the chronic toxicity of…

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Pediatric Lupus—Are There Differences in Presentation, Genetics, Response to Therapy, and Damage Accrual Compared with Adult Lupus?

Oct 1, 2017 by in RHEUMATOLOGY Comments Off on Pediatric Lupus—Are There Differences in Presentation, Genetics, Response to Therapy, and Damage Accrual Compared with Adult Lupus?

Some complement deficiencies predispose to systemic lupus erythematosus (SLE) early in life. Currently, there are no known unique physiologic or genetic pathways that can explain the variability in disease phenotypes….

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