RHEUMATOLOGY

Epidemiology in Rheumatology

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on Epidemiology in Rheumatology

Fig. 2.1 Types of variables Continuous variables can exhibit infinite values between the minimum and maximum. For example, WOMAC can take any score from 0 to 2400 mm as in…

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Arthritis

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on Arthritis

Clinical patterns Important clinical features Prevalence Asymmetric oligoarthritis ≤4 joints involved Asymmetric in distribution Most common ~20–55% [5] Symmetric polyarthritis ≥5 joints involved Symmetric in distribution Similar to rheumatoid arthritis…

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Manifestations of Systemic Diseases

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on Manifestations of Systemic Diseases

Fig. 18.1 Avascular necrosis of the left hip in a patient with sickle cell disease (Reprinted with permission from Springer [2]) Acromegaly is characterized by hypersecretion of growth hormone (GH) and…

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Syndrome

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on Syndrome

Fig. 10.1 A model of potential contribution of different factors in SS pathogenesis Table 10.1 Association of non-MHC class genes with SS susceptibility according to distinct pathogenetic pathways   Type I…

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Arthritis

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on Arthritis

2010 ACR/EULAR classification criteria for RA Joint involvement 1 medium/large joint 2–10 medium joints 1–3 small joints 4–10 small joints >10 joints 0–5 points 0 1 2 3 5 Serology…

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Basis of Inflammatory Arthritides

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on Basis of Inflammatory Arthritides

Pathogenetic concept Consequences Autoimmunity Mucosal initiation Self-protein modifications Ag presentation by the SE Ab production Citrullination of self-proteins in the lung generates neoepitopes, which are presented by the shared epitope…

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Arthritis

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on Arthritis

   Points Clinical   Pattern of joint or bursa involvement during past or present symptomatic episodes Ankle or midfoot without first MTP joint 1 First MTP joint involved 2 Number of…

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Lupus Erythematosus (SLE)

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on Lupus Erythematosus (SLE)

American College of Rheumatology revised SLE classification criteria Systemic Lupus International Collaborating Clinics (SLICC) criteria Classification as SLE requires 4 out of 11 criteria Classification as SLE requires either 4…

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Diseases

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on Diseases

Monogenic periodic fever syndromes  FMF (familial Mediterranean fever)  MKD (mevalonate kinase deficiency)  NLRP3-AID (NLRP3-associated autoinflammatory disease)  TRAPS (TNF receptor-associated periodic fever syndrome)  NLRP12-AID (NLRP12-associated autoinflammatory disease) NOD2-associated diseases  Blau syndrome…

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