RHEUMATOLOGY

14. Osteoporosis

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on 14. Osteoporosis

Endocrine abnormalities Cushing’s syndrome, hyperthyroidism, hypogonadism hyperparathyroidism, hypercalciuria, hyperprolactinemia, Panhypopituitarism, diabetes, androgen insensitivity Hematological disorders Multiple myeloma, leukemia, lymphoma, systemic mastocytosis, hemophilia, thalassemia, monoclonal gammopathies Rheumatologic Rheumatoid arthritis, systemic lupus…

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Spondyloarthritis

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on Spondyloarthritis

Axial SpA Peripheral SpA Back pain ≥3 months Age of onset <45 years Peripheral arthritis and/or enthesitis and/or dactylitis and either column below Sacroiliitis on imaging (Acute inflammation on MRI OR definite…

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Genetics in Rheumatology

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on Genetics in Rheumatology

Classification Clinical features Gene/chromosome/OMIM Protein Inheritance Monogenic periodic fevers Familial Mediterranean fever (FMF) Recurrent febrile episodes with serositis and arthritis. Long-term development of AA amyloidosis in untreated patients. Good clinical…

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12. Vasculitis

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on 12. Vasculitis

Fig. 12.1 Giant cell arteritis. The wall of this muscular artery is diffusely involved by granulomatous inflammation, including scattered multinucleated giant cells, with significant loss of the muscular media and…

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Sclerosis (Scleroderma)

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on Sclerosis (Scleroderma)

Cell Pathogenic effects Fibroblasts Produce collagen and other extracellular matrix molecules Adipocytes, endothelial cells, epithelial cells Undergo transition to myofibroblasts expressing a smooth actin and producing collagen T cells Are…

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3. Osteoarthritis

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on 3. Osteoarthritis

Fig. 3.1 OA pathophysiology. The pathophysiology of OA involves a variety of systemic and local factors, including trauma, aging, obesity, epigenetic, and genetic factors. Chronic inflammation plays a strong role,…

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Arthritis

Oct 24, 2020 by in RHEUMATOLOGY Comments Off on Arthritis

  Joint involvement Pathogen Soft tissue skin infection Monoarticular, polyarticular S. aureus Streptococcus Sexually active Polyarticular Neisseria gonorrhoeae Elderly, UTI, skin breakdown Monoarticular Gram-negative rods including enteric organisms IVDU Sternoclavicular,…

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Osteochondral Autograft Transplantation/Mosaicplasty

Jun 26, 2020 by in RHEUMATOLOGY Comments Off on Osteochondral Autograft Transplantation/Mosaicplasty

10.1055/b-0034-92485 Osteochondral Autograft Transplantation/MosaicplastyBrett McCoy and Anthony Miniaci Healthy articular cartilage transmits load to subchondral bone while minimizing friction between articulating surfaces.1 Articular cartilage has minimal inherent healing potential, and…

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Toward Engineering a Biological Joint Replacement

Jun 26, 2020 by in RHEUMATOLOGY Comments Off on Toward Engineering a Biological Joint Replacement

10.1055/b-0034-92489 Toward Engineering a Biological Joint ReplacementGrace D. O′Connell, Eric G. Lima, Liming Bian, Nadeen O. Chahine, Michael B. Albro, James L. Cook, Gerard A. Ateshian, and Clark T. Hung…

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