T Lymphocytes
13 T Lymphocytes Ralph C. Budd, Karen A. Fortner Key Points T cells develop primarily in the thymus. The importance of the thymus is underscored by the complete absence of…
Polyarticular Arthritis
42 Polyarticular Arthritis John J. Cush, Kathryn H. Dao Key Points Polyarthritis is pain of synovial or articular origin, with or without inflammation, in four or more joints. The history…
Pathogenesis of Ankylosing Spondylitis and Reactive Arthritis
74 Pathogenesis of Ankylosing Spondylitis and Reactive Arthritis David Yu, Rik Lories, Robert D. Inman Key Points Genetics plays a major role in the etiology of ankylosing spondylitis. The gene…
Etiology and Pathogenesis of Juvenile Idiopathic Arthritis
106 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis Lucy R. Wedderburn, Kiran Nistala Key Points Juvenile idiopathic arthritis (JIA) is a group of conditions with distinct clinical phenotypes and likely…
Autoimmunity
20 Autoimmunity Dwight H. Kono, Argyrios N. Theofilopoulos Key Points Autoimmunity ranges from physiologic autoreactivity to overt autoimmune disease, in part reflecting the complexity of the immune system, the presence…
Primary Angiitis of the Central Nervous System
92 Primary Angiitis of the Central Nervous System Rula A. Hajj-Ali, Carol A. Langford Key Points Primary angiitis of the central nervous system (PACNS) is defined as vasculitis that is…
Neural Regulation of Pain and Inflammation
29 Neural Regulation of Pain and Inflammation Rainer H. Straub Key Points The sensory nervous system regulates peripheral inflammation, including release of mediators such as substance P and calcitonin gene–related…
Mast Cells
16 Mast Cells Peter A. Nigrovic, David M. Lee Key Points Mast cells arise in the bone marrow, circulate as immature precursors, and develop into functional mast cells upon entering…
Rheumatologic Manifestations of Hemoglobinopathies
120 Rheumatologic Manifestations of Hemoglobinopathies Brian Mandell Key Points The hemoglobinopathies differ in their pattern and severity of musculoskeletal manifestations. Sickle cell disease is characterized by painful vaso-occlusive crises, which…
Innate Immunity
18 Innate Immunity Steven A. Porcelli Key Points Innate immunity depends on recognition of conserved molecular patterns found in many microorganisms. Several families of pattern recognition receptors are responsible for…
