67 Psychosocial Management of Rheumatic Diseases W. Neal Roberts, Jr. Key Points Treatment of unrecognized depression is probably the psychosocial intervention with the greatest impact and is frequently required. Matching…
22 Epigenetics Caroline Ospelt, Steffen Gay Key Points Epigenetic changes have a lasting effect on gene expression by modification of histone tails and DNA. DNA methylation silences gene expression, while…
36 Cardiovascular Risk in Rheumatic Disease Sherine E. Gabriel, Deborah Symmons Key Points For nearly half a century, excess rates of cardiovascular disease (CVD) have been reported among patients with…
35 Occupational and Recreational Musculoskeletal Disorders Karina D. Torralba, Richard S. Panush Key Points Some occupational and recreational activities have been linked with musculoskeletal syndromes or disorders. These include certain…
34 Biologic Markers Jeroen DeGroot, Anne-Marie Zuurmond, Paul-Peter Tak Key Points Uniform definitions of disease are essential for biomarker validation and comparison among studies. The validation process of a biomarker…
41 Acute Monoarthritis Max Field Key Points Inflammatory arthritis causes morning stiffness and pain with restricted joint movement. Pain worsening after movement usually indicates mechanical joint pain. Soft tissue disorders…
38 Introduction to Physical Medicine, Physical Therapy, and Rehabilitation Maura Daly Iversen Key Points The aims of rehabilitation are to maximize function and minimize activity limitation and participation restriction. The…
4 Biology, Physiology, and Morphology of Bone Georg Schett Key Points Intramembranous or endochondral ossification generates the bone tissue. Bones consist of a dense cortical shell and sponge-like trabecular network…
37 Cancer Risk in Rheumatic Diseases Eric L. Matteson Key Points Risk of malignancy, especially lymphoproliferative malignancy, is increased in autoimmune rheumatic diseases. The occurrence of cancer in patients with…
