Biology of the Normal Joint
1 Biology of the Normal Joint Steven R. Goldring, Mary B. Goldring Key Points Condensation of mesenchymal cells, which differentiate into chondrocytes, results in formation of cartilage anlagen, which provide…
Musculoskeletal Syndromes in Malignancy
122 Musculoskeletal Syndromes in Malignancy Eliza F. Chakravarty Key Points Musculoskeletal and rheumatic syndromes can occasionally be the first presentation of an underlying malignancy. Older age of onset, prominent constitutional…
Nutrition and Rheumatic Diseases
68 Nutrition and Rheumatic Diseases Lisa K. Stamp, Leslie G. Cleland Key Points Nutritional factors can have proinflammatory or anti-inflammatory effects, or both. Nutritional factors have been implicated in the…
Behçet’s Disease
93 Behçet’s Disease William S. Kaufman, Elizabeth Kaufman McNamara, Joseph L. Jorizzo Key Points Behçet’s disease is a complex multisystem disease characterized by oral and genital ulcers and other systemic…
Fibromyalgia
52 Fibromyalgia Frederick Wolfe, Johannes J. Rasker Key Points Many issues that surround fibromyalgia are not scientific ones—it is widely agreed that pain and suffering are real; instead, the primary…
Etiology and Pathogenesis of Systemic Lupus Erythematosus
79 Etiology and Pathogenesis of Systemic Lupus Erythematosus Mary K. Crow Key Points Systemic lupus erythematosus (SLE) results from chronic and recurrent activation of the immune system, with production of…
Autoantibodies in Rheumatoid Arthritis
56 Autoantibodies in Rheumatoid Arthritis Felipe Andrade, Erika Darrah, Antony Rosen Key Points Autoantibodies in rheumatoid arthritis (RA) are important tools for diagnosis and for defining important pathogenic pathways in…
Fibroblasts and Fibroblast-like Synoviocytes
15 Fibroblasts and Fibroblast-like Synoviocytes Andrew Filer, Christopher D. Buckley Key Points Fibroblasts are programmed epigenetically to determine the unique structure and function of different organs and tissues. However, these…
Classification and Epidemiology of Systemic Vasculitis
87 Classification and Epidemiology of Systemic Vasculitis John H. Stone Key Points Vasculitis is a heterogeneous group of disorders linked by the primary finding of inflammation within blood vessel walls….
Principles of Epidemiology in Rheumatic Disease
30 Principles of Epidemiology in Rheumatic Disease Yvonne M. Golightly, Joanne M. Jordan Key Points Epidemiology is the study of the distribution of disease and its determinants in populations. Epidemiologic…
