Osteoarthritis: Clinical Presentations Michele M. Hooper Roland W. Moskowitz The symptomatic osteoarthritic joint presents with pain, limited range of motion, and stiffness; but symptoms are highly variable, depending on which…
Molecular Genetics of Osteoarthritis John Loughlin Kay Chapman Outline There has long been a suspicion that genes play a role in the development of osteoarthritis (OA). However, it is only…
Experimental Models of Osteoarthritis Margaret M. Smith Christopher B. Little Although the etiopathogenesis of osteoarthritis (OA) is still the subject of intense debate and research, its pathology is well established.1…
Cell Biology, Biochemistry, and Molecular Biology of Articular Cartilage in Osteoarthritis Linda J. Sandell Dick Heinegard Thomas M. Hering Cartilage: Tissue Organization Articular cartilage is comprised largely of an extracellular…
Pathology of Osteoarthritis Aubrey J. Hough Jr. Historical Concepts of Osteoarthritis Medical science is to a degree inseparable from its ancient origins in so-called natural philosophy. Disease itself was originally…
Etiopathogenesis of Osteoarthritis A. Robin Poole Farshid Guilak Steven B. Abramson Osteoarthritis (OA) is a condition that represents a pathological imbalance of degradative and reparative processes involving the whole joint…
Features of Osteoarthritis at Specific Sites Features of osteoarthritis of the knee The knee is comprised of one synovial cavity with three principle compartments: the medial and lateral tibiofemoral joints,…
Epidemiology of Osteoarthritis Leena Sharma Dipali Kapoor Introduction Osteoarthritis (OA) is the most common form of arthritis and a leading cause of chronic disability, in large part due to knee…
Subsets of Osteoarthritis Generalized osteoarthritis Early epidemiological studies using radiological surveys detailed the fact that many patients had osteoarthritis of multiple joints, suggesting a generalized, in-built predisposition (3.1). Furthermore, the…
Principles of Management Introduction In the management of osteoarthritis, there are several tools available (5.1). There are a wide number of options, including non-pharmacological, pharmacological, and surgical options, which may…
