Antihyperuricemic Agents
65 Antihyperuricemic Agents Ted R. Mikuls Key Points Urate-lowering therapy (ULT) is central to the management of hyperuricemia in gout. The goal of ULT administration in gout is to reduce…
Proteinases and Matrix Degradation
8 Proteinases and Matrix Degradation Yasunori Okada Key Points Proteinases are generally classified into aspartic proteinases, cysteine proteinases, serine proteinases, and metalloproteinases according to catalytic mechanism. Because of the acidic…
Immunosuppressive Drugs
62 Immunosuppressive Drugs Jacob M. Van Laar Key Points Immunosuppressive drugs are effective and indispensable as remission inducing and maintenance agents in the management of inflammatory rheumatic conditions. They constitute…
Reactive Arthritis and Undifferentiated Spondyloarthritis
76 Reactive Arthritis and Undifferentiated Spondyloarthritis J.S. Hill Gaston Key Points Reactive arthritis is a form of spondyloarthritis triggered by particular infections. Undifferentiated spondyloarthritis can have both peripheral and axial…
Ankylosing Spondylitis
75 Ankylosing Spondylitis Sjef M. van der Linden, Dominique Baeten, Walter P. Maksymowych Key Points The concept of axial spondyloarthritis comprises both nonradiographic axial disease and ankylosing spondylitis (AS) according…
Antiphospholipid Syndrome
82 Antiphospholipid Syndrome Doruk Erkan, Jane E. Salmon, Michael D. Lockshin Key Points Antiphospholipid antibodies (aPLs) are a family of autoantibodies directed against phospholipid-binding plasma proteins, most commonly β2-glycoprotein I….
Biology of the Normal Joint
1 Biology of the Normal Joint Steven R. Goldring, Mary B. Goldring Key Points Condensation of mesenchymal cells, which differentiate into chondrocytes, results in formation of cartilage anlagen, which provide…
Musculoskeletal Syndromes in Malignancy
122 Musculoskeletal Syndromes in Malignancy Eliza F. Chakravarty Key Points Musculoskeletal and rheumatic syndromes can occasionally be the first presentation of an underlying malignancy. Older age of onset, prominent constitutional…
Nutrition and Rheumatic Diseases
68 Nutrition and Rheumatic Diseases Lisa K. Stamp, Leslie G. Cleland Key Points Nutritional factors can have proinflammatory or anti-inflammatory effects, or both. Nutritional factors have been implicated in the…
Behçet’s Disease
93 Behçet’s Disease William S. Kaufman, Elizabeth Kaufman McNamara, Joseph L. Jorizzo Key Points Behçet’s disease is a complex multisystem disease characterized by oral and genital ulcers and other systemic…
