Foot and Ankle Pain
49 Foot and Ankle Pain Mark D. Price, Christopher P. Chiodo Key Points The differential diagnosis for foot and ankle pain is vast. Localizing symptoms by anatomic region helps narrow…
Pregnancy in the Rheumatic Diseases
39 Pregnancy in the Rheumatic Diseases Eliza F. Chakravarty, Megan E. Clowse Key Points The majority of women with autoimmune diseases will have healthy and uneventful pregnancies, and the risk-benefit…
Experimental Models for Rheumatoid Arthritis
28 Experimental Models for Rheumatoid Arthritis Rikard Holmdahl Key Points Animal models are tools to mimic various aspects of rheumatoid arthritis (RA). There are many different animal models for RA,…
T Lymphocytes
13 T Lymphocytes Ralph C. Budd, Karen A. Fortner Key Points T cells develop primarily in the thymus. The importance of the thymus is underscored by the complete absence of…
Polyarticular Arthritis
42 Polyarticular Arthritis John J. Cush, Kathryn H. Dao Key Points Polyarthritis is pain of synovial or articular origin, with or without inflammation, in four or more joints. The history…
Pathogenesis of Ankylosing Spondylitis and Reactive Arthritis
74 Pathogenesis of Ankylosing Spondylitis and Reactive Arthritis David Yu, Rik Lories, Robert D. Inman Key Points Genetics plays a major role in the etiology of ankylosing spondylitis. The gene…
Etiology and Pathogenesis of Juvenile Idiopathic Arthritis
106 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis Lucy R. Wedderburn, Kiran Nistala Key Points Juvenile idiopathic arthritis (JIA) is a group of conditions with distinct clinical phenotypes and likely…
Autoimmunity
20 Autoimmunity Dwight H. Kono, Argyrios N. Theofilopoulos Key Points Autoimmunity ranges from physiologic autoreactivity to overt autoimmune disease, in part reflecting the complexity of the immune system, the presence…
Primary Angiitis of the Central Nervous System
92 Primary Angiitis of the Central Nervous System Rula A. Hajj-Ali, Carol A. Langford Key Points Primary angiitis of the central nervous system (PACNS) is defined as vasculitis that is…
Neural Regulation of Pain and Inflammation
29 Neural Regulation of Pain and Inflammation Rainer H. Straub Key Points The sensory nervous system regulates peripheral inflammation, including release of mediators such as substance P and calcitonin gene–related…
