122 Musculoskeletal Syndromes in Malignancy Eliza F. Chakravarty Key Points Musculoskeletal and rheumatic syndromes can occasionally be the first presentation of an underlying malignancy. Older age of onset, prominent constitutional…
68 Nutrition and Rheumatic Diseases Lisa K. Stamp, Leslie G. Cleland Key Points Nutritional factors can have proinflammatory or anti-inflammatory effects, or both. Nutritional factors have been implicated in the…
93 Behçet’s Disease William S. Kaufman, Elizabeth Kaufman McNamara, Joseph L. Jorizzo Key Points Behçet’s disease is a complex multisystem disease characterized by oral and genital ulcers and other systemic…
52 Fibromyalgia Frederick Wolfe, Johannes J. Rasker Key Points Many issues that surround fibromyalgia are not scientific ones—it is widely agreed that pain and suffering are real; instead, the primary…
79 Etiology and Pathogenesis of Systemic Lupus Erythematosus Mary K. Crow Key Points Systemic lupus erythematosus (SLE) results from chronic and recurrent activation of the immune system, with production of…
56 Autoantibodies in Rheumatoid Arthritis Felipe Andrade, Erika Darrah, Antony Rosen Key Points Autoantibodies in rheumatoid arthritis (RA) are important tools for diagnosis and for defining important pathogenic pathways in…
15 Fibroblasts and Fibroblast-like Synoviocytes Andrew Filer, Christopher D. Buckley Key Points Fibroblasts are programmed epigenetically to determine the unique structure and function of different organs and tissues. However, these…
87 Classification and Epidemiology of Systemic Vasculitis John H. Stone Key Points Vasculitis is a heterogeneous group of disorders linked by the primary finding of inflammation within blood vessel walls….
30 Principles of Epidemiology in Rheumatic Disease Yvonne M. Golightly, Joanne M. Jordan Key Points Epidemiology is the study of the distribution of disease and its determinants in populations. Epidemiologic…
121 Endocrine Diseases and the Musculoskeletal System Maurizio Cutolo Key Points Both hypothyroidism and hyperthyroidism are characterized by frequent symptomatic involvement of the musculoskeletal system. Diseases of the parathyroid gland…
