Neutrophils
11 Neutrophils Jose U. Scher, Steven B. Abramson, Michael H. Pillinger Key Points Neutrophils are myeloid-lineage cells characterized by the presence of granules containing enzymes and other potentially toxic agents…
Clinical Features and Treatment of Gout
95 Clinical Features and Treatment of Gout Christopher M. Burns, Robert L. Wortmann Key Points Hyperuricemia is defined as a serum urate level greater than 6.8 mg/dL. Acute gout can be…
Amyloidosis
116 Amyloidosis David C. Seldin, Martha Skinner Key Points Amyloidosis is the term for systemic disease in which aggregated proteins form extracellular fibrils in tissues of the body, eventually leading…
Glucocorticoid Therapy
60 Glucocorticoid Therapy Johannes W.G. Jacobs, Johannes W.J. Bijlsma Key Points Mode of action of glucocorticoids is genomic (via glucocorticoid receptor) and, in high dosages, also nongenomic. Glucocorticoids differ considerably…
Traditional DMARDs: Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies
61 Traditional DMARDs Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies Amy C. Cannella, James R. O’dell Key Points Methotrexate is one of the most durable and frequently used disease-modifying antirheumatic…
Hand and Wrist Pain
50 Hand and Wrist Pain Carrie R. Swigart Key Points Patients with carpal tunnel syndrome typically present with nocturnal paresthesias associated with intermittent pain or paresthesia during the day. Ganglia…
Temporomandibular Joint Pain
51 Temporomandibular Joint Pain Daniel M. Laskin Key Points Temporomandibular joint (TMJ) pain must be distinguished from the pain that more commonly arises from the muscles of mastication (myofascial pain),…
Bacterial Arthritis
109 Bacterial Arthritis Paul P. Cook, Dawd S. Siraj Key Points Acute bacterial arthritis is a medical emergency that warrants rapid, accurate diagnosis and immediate treatment along with appropriate consultation…
The Eye and Rheumatic Diseases
44 The Eye and Rheumatic Diseases James T. Rosenbaum Key Points Symptoms of uveitis vary widely based on the location of the inflammation within the eye and the suddenness of…
History and Physical Examination of the Musculoskeletal System
40 History and Physical Examination of the Musculoskeletal System John M. Davis, III., Kevin G. Moder, Gene G. Hunder Key Points Taking a detailed and accurate history is crucial for…
