History of Nitisinone (NTBC)
Fig. 26.1 Callistemon spp. (Australian bottle-brush plant) Animal toxicity studies were carried out at ICI and subsequently Zeneca, which was established in 1993 by demerging of various business units of…
Analysis of X-Ray Symptomatology of Ochronotic Arthropathy in Spine
Fig. 12.1 Cervical spine: head in forward projection. Narrowing of intervertebral spaces with considerable subchondral sclerotisation of articular surfaces and non-homogeneous mild opacity of intervertebral spaces, uncovertebral arthrosis and arthrosis…
Manifestations of Alkaptonuria and Ochronosis in the Respiratory Tract
Fig. 19.1 Ochronosis and its location in the cartilaginous skeleton of the lower respiratory tract: (a) The cartilaginous skeleton from the front side – the places with considerable ochronotic colouration…
Manifestations of Alkaptonuric Ochronosis in the Eye
Fig. 16.1 (a, b) Ochronotic pigmentations on scleras in patients affected by ochronotic arthropathy According to our findings, the first traces of pigment appear in a horizontal plane 4–6 mm…
Pathological Anatomy and Histology of Ochronosis
Fig. 20.1 Ochronosis in joint tissues. Histological images of the connective tissue from the tendons and fibrous capsule of a patient with AKU showing deposition of ochronotic pigment (a–g). Photographs…
Metabolism of Aromatic Amino Acids
Fig. 4.1 Conversion of phenylalanine to tyrosine 1. Fumarate and acetoacetate 2. Dopamine, adrenaline and noradrenaline 3. Melanins 4. Thyroid hormones – thyroxin and triiodothyronine Degradation…
Therapy of Alkaptonuria
© Springer International Publishing Switzerland 2015Jozef Rovenský, Tibor Urbánek, Boldišová Oľga and James A. Gallagher (eds.)Alkaptonuria and Ochronosis10.1007/978-3-319-15108-3_25 25. Therapy of Alkaptonuria Jozef Rovenský1, 2 and Tibor Urbánek1 (1) National Institute of Rheumatic Diseases, Piešťany, Slovakia (2) Institute of…
Coincidence of Alkaptonuric Ochronosis with Other Diseases
© Springer International Publishing Switzerland 2015Jozef Rovenský, Tibor Urbánek, Boldišová Oľga and James A. Gallagher (eds.)Alkaptonuria and Ochronosis10.1007/978-3-319-15108-3_23 23. Coincidence of Alkaptonuric Ochronosis with Other Diseases Jozef Rovenský1, 2 and Oľga Lukáčová1 (1) National Institute of Rheumatic Diseases, Piešťany,…
Differential Diagnosis of the Disease
© Springer International Publishing Switzerland 2015Jozef Rovenský, Tibor Urbánek, Boldišová Oľga and James A. Gallagher (eds.)Alkaptonuria and Ochronosis10.1007/978-3-319-15108-3_24 24. Differential Diagnosis of the Disease Jozef Rovenský1, 2 and Oľga Lukáčová1 (1) National Institute of Rheumatic Diseases, Piešťany, Slovakia (2)…
Rare Complications of Alkaptonuria: Haemolysis and Amyloidosis
© Springer International Publishing Switzerland 2015Jozef Rovenský, Tibor Urbánek, Boldišová Oľga and James A. Gallagher (eds.)Alkaptonuria and Ochronosis10.1007/978-3-319-15108-3_22 22. Rare Complications of Alkaptonuria: Haemolysis and Amyloidosis Richard Imrich1 , Jozef Rovenský2, 3 and Žofia Rádiková4 (1) Laboratory of Human Endocrinology, Center…
