10 Mononuclear Phagocytes in Rheumatic Diseases Siamon Gordon Key Points Macrophages play an important role in tissue homeostasis and in cellular and humoral innate and adaptive immunity. Macrophages, dendritic cells,…
105 Heritable Diseases of Connective Tissue Deborah Krakow Key Points Heritable disorders of connective tissues are a diverse group of disorders and can be associated with extreme variation in height…
64 Cell-Targeted Biologics and Targets Rituximab, Abatacept, and Other Biologics Peter C. Taylor Key Points Rituximab is an effective biologic therapy across the spectrum of rheumatoid arthritis (RA)-but with greatest…
27 Cell Survival and Death in Rheumatic Diseases Keith B. Elkon Key Points Cells die in different ways with the morphologic appearance of apoptosis, autophagy, or necrosis. Apoptosis proceeds through…
11 Neutrophils Jose U. Scher, Steven B. Abramson, Michael H. Pillinger Key Points Neutrophils are myeloid-lineage cells characterized by the presence of granules containing enzymes and other potentially toxic agents…
95 Clinical Features and Treatment of Gout Christopher M. Burns, Robert L. Wortmann Key Points Hyperuricemia is defined as a serum urate level greater than 6.8 mg/dL. Acute gout can be…
116 Amyloidosis David C. Seldin, Martha Skinner Key Points Amyloidosis is the term for systemic disease in which aggregated proteins form extracellular fibrils in tissues of the body, eventually leading…
60 Glucocorticoid Therapy Johannes W.G. Jacobs, Johannes W.J. Bijlsma Key Points Mode of action of glucocorticoids is genomic (via glucocorticoid receptor) and, in high dosages, also nongenomic. Glucocorticoids differ considerably…
61 Traditional DMARDs Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies Amy C. Cannella, James R. O’dell Key Points Methotrexate is one of the most durable and frequently used disease-modifying antirheumatic…
