91 Immune Complex–Mediated Small Vessel Vasculitis John H. Stone Key Points Vasculitis mediated by immune complexes (ICs) includes a heterogeneous group of disorders linked by inefficient or dysregulated clearance of…
59 Prostanoid Biology and Its Therapeutic Targeting Leslie J. Crofford Key Points Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective anti-inflammatory, antipyretic, and analgesic compounds. There is little difference in the efficacy…
80 Clinical Features of Systemic Lupus Erythematosus Maria Dall’Era, David Wofsy Key Points Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by a relapsing-remitting course and a highly…
104 Relapsing Polychondritis Gaye Cunnane Key Points Relapsing polychondritis is a rare disorder that classically affects the cartilaginous structures of the ears and nose, resulting in “cauliflower ear” and “saddle…
102 Proliferative Bone Diseases Reuven Mader Key Points Diffuse idiopathic skeletal hyperostosis (DISH) is usually defined by the presence of large flowing osteophytes connecting at least four vertebrae, typically in…
111 Mycobacterial Infections of Bones and Joints Eric M. Ruderman, John P. Flaherty Key Points Global rates of tuberculosis disease have increased due to the expanding human immunodeficiency virus pandemic…
117 Sarcoidosis Nadera J. Sweiss, Robert P. Baughman Key Points Sarcoidosis is a heterogeneous multisystem inflammatory disease of unknown cause characterized by the development and accumulation of noncaseating granulomata in…
112 Fungal Infections of Bones and Joints Eric M. Ruderman, John P. Flaherty Key Points Fungi are an infrequent but clinically important cause of bone and joint infections. These infections…
