Chapter 34 Hematologic and Lymphoid Abnormalities in SLE George A. Karpouzas Hematologic abnormalities are common in systemic lupus erythematosus (SLE) and are often presenting manifestations of the disease. Sometimes their…
Chapter 57 Mortality in SLE Sasha Bernatsky, Deborah Levy, Rosalind Ramsey-Goldman, Caroline Gordon, Anisur Rahman, Ann E. Clarke It is well known that systemic lupus erythematosus (SLE) can be severe…
Chapter 17 Animal Models of SLE Bevra Hannahs Hahn, Dwight Kono Animal models of SLE have provided an invaluable resource for defining disease pathophysiology, genetics, and therapeutic approaches. Furthermore, in…
Chapter 23 Pathomechanisms of Cutaneous Lupus Erythematosus Jan P. Dutz Abnormal cutaneous reactivity to sunlight is such a seminal clinical feature of lupus erythematosus (LE) that it is one of…
Chapter 49 Antimalarial Medications J. Antonio Aviña-Zubieta, John M. Esdaile Introduction Paine first used quinine for the treatment of discoid lupus erythematosus.1 It was not, however, until 1951, when Page…
Chapter 21 Autoantigenesis and Antigen-Based Therapy and Vaccination in SLE Ram Raj Singh, Julia Pinkhasov, Priti Prasad, Shweta Dubey1, The discovery in the early 1990s that self-antigen–reactive T cells can…
Chapter 3 The Pathogenesis of SLE Bevra H. Hahn The purpose of this brief chapter is to review how SLE evolves and is sustained. Ideas reflect the author’s opinions, which…
Chapter 36 Pregnancy in Women with SLE Megan E.B. Clowse Systemic lupus erythematosus (SLE) primarily affects women of childbearing age; pregnancy is therefore a dilemma frequently encountered in this patient…
Chapter 18 Pathogenetic Mechanisms in Lupus Nephritis Anne Davidson, Celine Berthier, Matthias Kretzler The kidneys maintain homeostasis of water, minerals, electrolytes, and hydrogen ions and eliminate toxic substances produced by…
Chapter 54 Critical Issues in Drug Development for SLE Ronald F. van Vollenhoven Introduction The development of new drugs for the treatment of systemic lupus erythematosus (SLE) during the first…
