Biologic Markers
34 Biologic Markers Jeroen DeGroot, Anne-Marie Zuurmond, Paul-Peter Tak Key Points Uniform definitions of disease are essential for biomarker validation and comparison among studies. The validation process of a biomarker…
Acute Monoarthritis
41 Acute Monoarthritis Max Field Key Points Inflammatory arthritis causes morning stiffness and pain with restricted joint movement. Pain worsening after movement usually indicates mechanical joint pain. Soft tissue disorders…
Introduction to Physical Medicine, Physical Therapy, and Rehabilitation
38 Introduction to Physical Medicine, Physical Therapy, and Rehabilitation Maura Daly Iversen Key Points The aims of rehabilitation are to maximize function and minimize activity limitation and participation restriction. The…
Biology, Physiology, and Morphology of Bone
4 Biology, Physiology, and Morphology of Bone Georg Schett Key Points Intramembranous or endochondral ossification generates the bone tissue. Bones consist of a dense cortical shell and sponge-like trabecular network…
Cancer Risk in Rheumatic Diseases
37 Cancer Risk in Rheumatic Diseases Eric L. Matteson Key Points Risk of malignancy, especially lymphoproliferative malignancy, is increased in autoimmune rheumatic diseases. The occurrence of cancer in patients with…
Dendritic Cells
9 Dendritic Cells Shaukat Khan, Merja Ruutu, Ranjeny Thomas, Nina Bhardwaj Key Points Dendritic cells (DCs) are professional antigen-presenting cells, abundant at body surfaces and within tissues, where they sense…
Clinical Trial Design and Analysis
32 Clinical Trial Design and Analysis Robert B.M. Landewé, Désirée M.F.M. van der Heijde Key Points Clinical trials play an important role in new drug development but also can serve…
Cell Recruitment and Angiogenesis
25 Cell Recruitment and Angiogenesis Zoltan Szekanecz, Alisa E. Koch Key Points Leukocyte recruitment through the vessel wall into the synovium is a crucial process in the pathogenesis of arthritis….
Regenerative Medicine and Tissue Engineering
7 Regenerative Medicine and Tissue Engineering Frank P. Luyten Key Points An understanding of the mechanisms of postnatal tissue repair provides potential therapeutic targets to enhance intrinsic tissue regeneration. Because…
