3 Cartilage and Chondrocytes Mary B. Goldring Key Points Articular cartilage matrix is heterogeneous and contains numerous extracellular matrix (ECM) proteins, of which the large aggregating proteoglycan aggrecan and collagen…
118 Hemochromatosis Gaye Cunnane Key Points Elevated ferritin (>200 µg/L) and transferrin saturation (>45%) in the absence of other causes are useful screening measures for hereditary hemochromatosis (HHC). Genetic testing should…
100 Treatment of Osteoarthritis Carlos J. Lozada Key Points Osteoarthritis (OA) is the most common form of arthritis. Pain is the most common symptom in patients with OA. The management…
114 Viral Arthritis Stanley J. Naides Key Points Acute-onset, symmetric polyarthritis can be caused by viral infection, especially when accompanied by rash. Always take exposure, travel, occupation, and vaccination histories….
65 Antihyperuricemic Agents Ted R. Mikuls Key Points Urate-lowering therapy (ULT) is central to the management of hyperuricemia in gout. The goal of ULT administration in gout is to reduce…
8 Proteinases and Matrix Degradation Yasunori Okada Key Points Proteinases are generally classified into aspartic proteinases, cysteine proteinases, serine proteinases, and metalloproteinases according to catalytic mechanism. Because of the acidic…
62 Immunosuppressive Drugs Jacob M. Van Laar Key Points Immunosuppressive drugs are effective and indispensable as remission inducing and maintenance agents in the management of inflammatory rheumatic conditions. They constitute…
76 Reactive Arthritis and Undifferentiated Spondyloarthritis J.S. Hill Gaston Key Points Reactive arthritis is a form of spondyloarthritis triggered by particular infections. Undifferentiated spondyloarthritis can have both peripheral and axial…
75 Ankylosing Spondylitis Sjef M. van der Linden, Dominique Baeten, Walter P. Maksymowych Key Points The concept of axial spondyloarthritis comprises both nonradiographic axial disease and ankylosing spondylitis (AS) according…
82 Antiphospholipid Syndrome Doruk Erkan, Jane E. Salmon, Michael D. Lockshin Key Points Antiphospholipid antibodies (aPLs) are a family of autoantibodies directed against phospholipid-binding plasma proteins, most commonly β2-glycoprotein I….
