Critical Issues in Drug Development for SLE
Chapter 54 Critical Issues in Drug Development for SLE Ronald F. van Vollenhoven Introduction The development of new drugs for the treatment of systemic lupus erythematosus (SLE) during the first…
Cardiopulmonary Disease in SLE
Chapter 27 Cardiopulmonary Disease in SLE Guillermo Ruiz-Irastorza, Munther Khamashta Cardiopulmonary Manifestations The heart and the lungs can frequently be affected during the course of systemic lupus erythematosus (SLE), because…
Immunosuppressive Drug Therapy
Chapter 50 Immunosuppressive Drug Therapy W. Joseph McCune, Tania Gonzalez-Rivera Immunosuppressive agents are widely used for serious manifestations of systemic lupus erythematosus (SLE) to minimize irreversible injury and reduce toxicity…
Systemic Glucocorticoid Therapy in SLE
Chapter 48 Systemic Glucocorticoid Therapy in SLE Kyriakos A. Kirou, Dimitrios T. Boumpas Glucocorticoids (GCs), as a result of their powerful antiinflammatory effects, have remained a frontline therapy in rheumatology…
The Musculoskeletal System and Bone Metabolism
Chapter 25 The Musculoskeletal System and Bone Metabolism Sandra V. Navarra, Tito P. Torralba Musculoskeletal manifestations involving the joints, muscle, bone, and supporting structures are common among patients with systemic…
Socioeconomic and Disability Aspects
Chapter 55 Socioeconomic and Disability Aspects Michael M. Ward Like many other chronic illnesses, systemic lupus erythematosus (SLE) can have a major impact on physical and social functioning and work…
Mixed Connective Tissue Disease and Undifferentiated Connective Tissue Disease
Chapter 41 Mixed Connective Tissue Disease and Undifferentiated Connective Tissue Disease Robert W. Hoffman, Eric L. Greidinger Mixed Connective Tissue Disease Historical Perspective The first full-length publication describing what the…
Neonatal Lupus Erythematosus
Chapter 37 Neonatal Lupus Erythematosus Marie Wahren-Herlenius, Sven-Erik Sonesson, Megan E.G. Clowse The association of neonatal cardiac and skin disease with maternal systemic lupus erythematosus (SLE) was first identified through…
SLE in Childhood and Adolescence
Chapter 40 SLE in Childhood and Adolescence Thomas J.A. Lehman Children and adolescents with systemic lupus erythematosus (SLE) represent both a special challenge and a special opportunity. Early onset allows…
Novel Therapies for SLE: Biological Agents Available in Practice Today
Chapter 53 Novel Therapies for SLE Biological Agents Available in Practice Today Ronald F. van Vollenhoven Introduction Only a very few medications are specifically approved by regulatory agencies for the…
