Review of Statistical Approaches for the Analysis of Data in Rheumatology
where X i represents here the DAS28 value for the ith patient and n = 159 is the size of the RAPPORT study. The symbol signifies that the sum is taken of…
of Traditional Randomized Controlled Clinical Trials in Rheumatology
Pragmatic limitations of clinical trials 1 A relatively short time frame in chronic diseases – sometimes too short to identify important clinical benefits or to recognize loss of efficacy 2…
Reviews and Meta-analyses in Rheumatology
Parameters that are commonly extracted from studies Characteristics of the manuscript Author Publication year Study duration Study design Factors related to risk of bias Participant characteristics Number Age Sex Diagnosis/criteria…
Genetic Association, and Genomic Studies
Fig. 1 Types of biomarkers that can be used at different stages of rheumatoid arthritis The majority of biomarkers in RA are also molecular like autoantibodies, cytokines, and acute-phase reactants….
Randomized Controlled Trial: Methodological Perspectives
, with is the α/2 quantile of a t-distribution with 2n − 2 degrees of freedom. These steps illustrate a few important things for computing the sample size: Clinicians must have a…
Directions
, Yusuf Yazici2 and Emmanuel Lesaffre3, 4 (1) Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey (2) Division of Rheumatology, NYU Hospital for Joint Diseases, New…
Issues in Study Design and Reporting
, Emmanuel Lesaffre2, 3 and Yusuf Yazici4 (1) Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey (2) Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (3)…
Issues Relevant to Observational Studies, Registries, and Administrative Health Databases in Rheumatology
RCTs Observational studies Strengths Randomization Large sample sizes and greater statistical power Blinding Greater external validity (more representative population) Limitations External validity is limited (usually highly selected population) Case…
Classification/Diagnosis Criteria
© Springer International Publishing Switzerland 2014Hasan Yazici, Yusuf Yazici and Emmanuel Lesaffre (eds.)Understanding Evidence-Based Rheumatology10.1007/978-3-319-08374-2_3 Disease Classification/Diagnosis Criteria Hasan Yazici1 and Yusuf Yazici2 (1) Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, Cerrahpasa Hospital, University of…
Measures in Rheumatoid Arthritis
Fig. 1 Radiographic outcomes in randomized controlled trials with methotrexate-naïve patients. TNF tumor necrosis factor inhibitor, MTX methotrexate, ETA etanercept, IFX infliximab, ADA adalimumab, ERA early rheumatoid arthritis (From Yazici…
