Fig. 36.1 The flow diagram showing pathway to osteonecrosis A so-called multiple-hit theory was proposed as a pathophysiologic mechanism directly through bone homeostasis alteration and cell injury and indirectly through…
Fig. 34.1 Schematic representation of phases of fracture repair, inflammation/hematoma, repair (soft callus and hard callus formation), remodeling The inflammation phase peaks at 24 h after initial fracture and continues…
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_29 29. Meniscus Scaffolds: 30 Years of Experience William G. Rodkey1 and Shu-Tung Li2 (1) Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, 181 West Meadow Drive,…
Characteristics Indications Side Approval Type of studies Outcomes Actifit® Polyurethane aliphatic, synthetic, biodegradable, acellular Partial meniscal replacement Lateral and medial Europe, Chile, South Africa Phase I and II Clinically…
Cell type Associated growth factors Leukocytes PDGF, VEGF Neutrophils MMP-9, IL-1B Monocytes IL-1B Platelets PDGF-AA, PDGF-AB, PDGF-BB, VEGF, TGF-B1 Data from [56] Up to 70% of growth factor content from…
Fig. 19.1 Schematic overview of skeletal muscle structure Skeletal muscle function is controlled by motor neurons that enter the muscle at the motor point. Each individual muscle fiber is contacted…
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_17 17. Stem Cells in Joint Repair Celeste Scotti1 , Kota Koizumi2, 3 and Norimasa Nakamura4, 5 (1) Musculoskeletal Translational Medicine, Novartis Institutes for Biomedical Research Basel, Novartis Pharma…
Vectors Capability of transferring genes into nondividing cells Maximum size of insert Stability of transgene expression Retro-/lentiviral vectors No (yes for lentiviral vectors) ≤8 kb Stable (random DNA insertion) Adenoviral…
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_13 13. Cell Culture Approaches for Articular Cartilage: Repair and Regeneration Eyitayo S. Fakunle1 and John G. Lane2 (1) Vericel Corporation, 64 Sidney Street, Cambridge, MA 02139, USA (2) Department…
Author Study design Scaffold Follow-up period Number of patients Age Gender Site Mean defect size (cm2) Kusano T, KSSTA 2012 [14] Retrospective study Collagen matrix 29 m 38a 26 y…
