Chapter 50 Immunosuppressive Drug Therapy W. Joseph McCune, Tania Gonzalez-Rivera Immunosuppressive agents are widely used for serious manifestations of systemic lupus erythematosus (SLE) to minimize irreversible injury and reduce toxicity…
Chapter 48 Systemic Glucocorticoid Therapy in SLE Kyriakos A. Kirou, Dimitrios T. Boumpas Glucocorticoids (GCs), as a result of their powerful antiinflammatory effects, have remained a frontline therapy in rheumatology…
Chapter 25 The Musculoskeletal System and Bone Metabolism Sandra V. Navarra, Tito P. Torralba Musculoskeletal manifestations involving the joints, muscle, bone, and supporting structures are common among patients with systemic…
Chapter 55 Socioeconomic and Disability Aspects Michael M. Ward Like many other chronic illnesses, systemic lupus erythematosus (SLE) can have a major impact on physical and social functioning and work…
Chapter 41 Mixed Connective Tissue Disease and Undifferentiated Connective Tissue Disease Robert W. Hoffman, Eric L. Greidinger Mixed Connective Tissue Disease Historical Perspective The first full-length publication describing what the…
Chapter 37 Neonatal Lupus Erythematosus Marie Wahren-Herlenius, Sven-Erik Sonesson, Megan E.G. Clowse The association of neonatal cardiac and skin disease with maternal systemic lupus erythematosus (SLE) was first identified through…
Chapter 40 SLE in Childhood and Adolescence Thomas J.A. Lehman Children and adolescents with systemic lupus erythematosus (SLE) represent both a special challenge and a special opportunity. Early onset allows…
Chapter 53 Novel Therapies for SLE Biological Agents Available in Practice Today Ronald F. van Vollenhoven Introduction Only a very few medications are specifically approved by regulatory agencies for the…
Chapter 11 Apoptosis, Necrosis, and Autophagy Keith B. Elkon Definitions Apoptosis The modern understanding of apoptosis began with the electron-microscopic descriptions of morphologic changes characterized by shrinkage of hepatocytes (i.e.,…
Chapter 15 Mechanisms of Acute Inflammation and Vascular Injury in SLE J. Michelle Kahlenberg, Mariana J. Kaplan Inflammation and injury of blood vessels in systemic lupus erythematosus (SLE) has been…
