Fig. 1.1 The mouse noninvasive tibia axial loading model. (a) Overview of the experimental design. (b) Loading-related osteogenesis labeled by calcein green on the first day of loading and alizarin…
Fig. 2.1 The mechanism of induction for cancer-induced bone pain. The acidic microenvironment created by activated osteoclast-stimulated nocicepotors, which results in skeletal pain as the mechanism observed for cancer-induced bone…
Fig. 9.1 (a) Changes in BMD of the lumbar spine after 5 years of treatment with alfacalcidol alone (D) or alfacalcidol and elcatonin (D + ECT). Data are presented as the mean + standard error…
Age AP-BMD L-BMD Mid-BMD FN-BMD TR-BMD WD-BMD Osteophyte score Disc score No. of vertebral fractures Age −0.218* −0.306** −0.254* −0.327** −0.328** −0.291* −0.027 0.016 0.295** AP-BMD 0.727*** 0.669*** 0.740***…
Fig. 5.1 Schematic representation why small loss in BMD could result in big loss in mechanical strength of the whole bone and why small gain in BMD could contribute to…
Syndromes/disorders OMIM Gene Acrofacial dysostosisa 263750 Alagille syndrome 118450 JAG1, NOTCH2 Anhalta 601344 Atelosteogenesis III 108721 FLNB Campomelic dysplasia 211970 SOX9 Casamassima-Morton-Nancea 271520 Caudal regressiona 182940 Cerebro-facio-thoracic dysplasiaa 213980 CHARGE…
Fig. 9.1 Timing and Genetic Consequence of de novo Mutations De novo mutation may occur at any time during embryonic development, ranging from prior to fertilization to after birth. Mutations…
Fig. 8.1 Radiographs showing (a) a case of SCDO with severe vertebral segmentation anomalies throughout the vertebral column (adapted from [51] with permission from Oxford University Press); and (b) a…
Fig. 2.1 Bone development cartoon (reprinted from publication title: Transcriptional mechanisms in osteoblast differentiation and bone formation. Trends in Genetics Volume 19, Issue 8, August 2003, Page 459, with permission…
Fig. 4.1 Schematic structure of DMP1 protein, gene and ARHR mutrations. a Schematic structure of the human DMP1 gene and ARHR mutations. DMP1 is composed of six exons. Because of…
