In Vitro Cartilage Explant Injury Models
Fig. 4.1 A load-controlled test apparatus to apply single or cyclic loads to multiple cartilage specimens. (A) Pneumatic air pistons to load the explants. (B) Piston rod with flat-bottom, cylindrical,…
Unanswered Questions and Future Directions in Post-Traumatic Arthritis
© Springer Science+Business Media New York 2015Steven A. Olson, MD and Farshid Guilak, PhD (eds.)Post-Traumatic Arthritis10.1007/978-1-4899-7606-2_28 28. Unanswered Questions and Future Directions in Post-Traumatic Arthritis Steven A. Olson1 and Farshid Guilak2 (1) Department of Orthopedic Surgery, Duke University…
Stem Cell Therapies for Post-Traumatic Arthritis
Title: A phase I/II, randomized, controlled, double-blind, study of chondrogen—adult universal cell delivered by intra-articular injection following meniscectomy in patients 18–60 years ClinicalTrials.gov Identifier: NCT00225095 Sponsor: Mesoblast International Sàrl Purpose:…
Potential Targets for Pharmacologic Therapies for Prevention of PTA
Drugs Mechanism of action In vitro effect on chondrocytes Pathology used for Effects reported in clinical studies Country performed at Oral vitamin E Antioxidant Improved chondrocyte viability Prevention of knee…
Non-arthroplasty Treatments for PTA in the Lower Extremity
Nonoperative NSAIDs Physical therapy Aquatic therapy Operative Hip arthrodesis PTA Knee: Nonoperative Let us assume for a moment that the treatment of osteoarthritis of the knee can be translated to…
Current Treatment and Outcomes of Intra-articular Fractures
Positively Negatively Anatomic reduction Posterior wall involvement Congruent joint reduction Articular step-off >2 mm Age <40 years Femoral head involvement/dislocation Age >55–60 years Intra-articular fracture fragmentation Osteonecrosis Fracture displacement >10–20…
Potential Mechanisms of PTOA: Inflammation
© Springer Science+Business Media New York 2015Steven A. Olson, MD and Farshid Guilak, PhD (eds.)Post-Traumatic Arthritis10.1007/978-1-4899-7606-2_16 16. Potential Mechanisms of PTOA: Inflammation Mary B. Goldring1 (1) Research Division, Tissue Engineering, Regeneration and Repair Program, The Hospital for…
Anterior Cruciate Transection/Disruption Models of Post-Traumatic Arthritis
Strain ACL-T type Surgery age Exp. time Results Reference Unknown Stab incision Unknown 1–26 weeks OA changes in articular cartilage (fibrillation, loss of cells in superficial layer); synovitis subsides within…
Post-Traumatic Arthritis: Definitions and Burden of Disease
© Springer Science+Business Media New York 2015Steven A. Olson, MD and Farshid Guilak, PhD (eds.)Post-Traumatic Arthritis10.1007/978-1-4899-7606-2_2 2. Post-Traumatic Arthritis: Definitions and Burden of Disease Joseph A. Buckwalter1, 2 and David T. Felson3 (1) Department of Orthopedics and Rehabilitation, University…
Arthritis That Develops After Joint Injury: Is It Post-Traumatic Arthritis or Post-Traumatic Osteoarthritis?
Fig. 1.1 A case presentation of a 40-year-old patient who sustains a posterior wall fracture of the acetabulum with subluxation of the femoral head. The patient reported no pre-injury hip…
