Infection and Autoimmunity
Chapter 15 Infection and Autoimmunity Brian D. Poole, PhD , Judith A. James, MD, PhD Infections are associated with both the etiology and morbidity of systemic lupus erythematosus (SLE). Mounting…
The Genetics of Lupus
Chapter 8 The Genetics of Lupus Bahram Namjou, MD , Jennifer A. Kelly, MPH , John B. Harley, MD, PhD INTRODUCTION Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune…
Genes and Genetics of Murine Lupus
Chapter 18 Genes and Genetics of Murine Lupus Shozo Izui, MD INTRODUCTION Systemic lupus erythematosus (SLE) is a disorder of systemic autoimmunity characterized by the formation of a variety of…
Immune Complexes in Systemic Lupus Erythematosus
Chapter 21 Immune Complexes in Systemic Lupus Erythematosus Mark H. Wener, MD INTRODUCTION Antigen-antibody complexes mediate much of the inflammation and tissue dysfunction associated with SLE. Deposition of ICs within…
Autoantibodies in Systemic Lupus Erythematosus
Chapter 16 Autoantibodies in Systemic Lupus Erythematosus David Isenberg, MD , Matthew Adler, MRCP INTRODUCTION Overview of Autoantibodies in SLE One of the hallmarks of systemic lupus erythematosus (SLE) is…
Role of Complement in Systemic Lupus Erythematosus Pathogenesis
Chapter 20 Role of Complement in Systemic Lupus Erythematosus Pathogenesis Chau-Ching Liu, MD, PhD , Jeannine S. Navratil, MS , Amy H. Kao, MD, MPH , Susan Manzi, MD, MPH…
Complement Deficiencies in Human Systemic Lupus Erythematosus (SLE) and SLE Nephritis: Epidemiology and Pathogenesis
Chapter 19 Complement Deficiencies in Human Systemic Lupus Erythematosus (SLE) and SLE Nephritis: Epidemiology and Pathogenesis C. Yung Yu, Dphil , Georges Hauptmann, MD, PhD , Yan Yang, MD, PhD…
Biology of Dendritic Cells
Chapter 13 Biology of Dendritic Cells Virginia Pascual, MD , A. Karolina Palucka, MD , Jacques Banchereau, MD INTRODUCTION The primary role of the immune system is to protect the…
Antibodies to DNA
Chapter 22A Antibodies to DNA David S. Pisetsky, MD, PhD INTRODUCTION Antibodies to DNA (anti-DNA) are prototypic autoantibodies that are the serologic hallmark of systemic lupus erythematosus (SLE). These antibodies…
Quality of Life and Economic Aspects
Chapter 4 Quality of Life and Economic Aspects Ann E. Clarke, MD, MSc , Pantelis Panopalis, MD INTRODUCTION Systemic lupus erythematosus (SLE) primarily affects young women in the prime of…
