Tissue Engineering and New Biomaterials
Extracellular matrix in native tissue Functions of scaffolds Features of scaffold – Provides structural support for cells – Should provide structural support for in vitro seeded cells – Should have binding…
Overview of Orthobiology and Biomechanics
Fig. 2.1 Tissue biomechanical assessment option diagram The purpose of this chapter is to review the current treatment options and the existing literature on outcomes, complications, and safety profile of…
Avascular Necrosis of the Hip
Fig. 36.1 The flow diagram showing pathway to osteonecrosis A so-called multiple-hit theory was proposed as a pathophysiologic mechanism directly through bone homeostasis alteration and cell injury and indirectly through…
Bone Anatomy and the Biologic Healing Process of a Fracture
Fig. 34.1 Schematic representation of phases of fracture repair, inflammation/hematoma, repair (soft callus and hard callus formation), remodeling The inflammation phase peaks at 24 h after initial fracture and continues…
Meniscus Scaffolds: 30 Years of Experience
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_29 29. Meniscus Scaffolds: 30 Years of Experience William G. Rodkey1 and Shu-Tung Li2 (1) Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, 181 West Meadow Drive,…
Meniscus Restoration
Characteristics Indications Side Approval Type of studies Outcomes Actifit® Polyurethane aliphatic, synthetic, biodegradable, acellular Partial meniscal replacement Lateral and medial Europe, Chile, South Africa Phase I and II Clinically…
The Use of PRP in Athletes with Muscular Lesions or Classification of PRP Preparations
Cell type Associated growth factors Leukocytes PDGF, VEGF Neutrophils MMP-9, IL-1B Monocytes IL-1B Platelets PDGF-AA, PDGF-AB, PDGF-BB, VEGF, TGF-B1 Data from [56] Up to 70% of growth factor content from…
Emerging Biological Approaches to Muscle Injuries
Fig. 19.1 Schematic overview of skeletal muscle structure Skeletal muscle function is controlled by motor neurons that enter the muscle at the motor point. Each individual muscle fiber is contacted…
Stem Cells in Joint Repair
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_17 17. Stem Cells in Joint Repair Celeste Scotti1 , Kota Koizumi2, 3 and Norimasa Nakamura4, 5 (1) Musculoskeletal Translational Medicine, Novartis Institutes for Biomedical Research Basel, Novartis Pharma…
Gene Therapy
Vectors Capability of transferring genes into nondividing cells Maximum size of insert Stability of transgene expression Retro-/lentiviral vectors No (yes for lentiviral vectors) ≤8 kb Stable (random DNA insertion) Adenoviral…
