Retinoblastoma
Retinoblastoma Murali M. Chintagumpala EPIDEMIOLOGY Retinoblastoma is a rare, highly malignant tumor of the retina of young children. Retinoblastoma is the seventh most common pediatric malignancy in the United States….
Soft-Tissue Sarcomas
Soft-Tissue Sarcomas Murali M. Chintagumpala The soft-tissue sarcomas form a diverse group of malignant neoplasms that arise from embryonal mesenchyma. As a group, these tumors are rare in children, and…
Neuroblastoma
Neuroblastoma Douglas R. Strother Heidi V. Russell Neuroblastic tumors, which include neuroblastoma, ganglioneuroblastoma, and ganglioneuroma, develop from neural crest tissue. They cover a spectrum from highly malignant to benign in…
Wilms Tumor
Wilms Tumor Murali M. Chintagumpala Wilms tumor is a malignant embryonal neoplasm of the kidney of mixed cellular histology. The incidence remains remarkably constant, with 8.1 cases per million white…
Malignant Brain Tumors
Malignant Brain Tumors Murali M. Chintagumpala Primary brain tumors are the second most common type of cancer reported in children and adolescents. In the United States, the annual incidence of…
Non-Hodgkin Lymphoma
Non-Hodgkin Lymphoma Kenneth L. McClain EPIDEMIOLOGY Non-Hodgkin lymphomas (NHLs) represent 6% of all tumors in the pediatric age group and are the fifth most frequent. The incidence per million children…
Hodgkin Disease
Hodgkin Disease Kenneth L. McClain EPIDEMIOLOGY Lymphomas (Hodgkin disease [HD] and non-Hodgkin lymphomas) together make up the third largest group of malignant diseases in children 0 to 19 years of…
Hematopoietic Stem Cell Transplantation for Childhood Leukemias
Hematopoietic Stem Cell Transplantation for Childhood Leukemias Ingrid Kuehnle C. Philip Steuber Hematopoietic stem cell transplantation (HSCT or SCT) is the process of replacing or substituting a patient’s diseased, defective,…
Chronic Myeloproliferative Disorders
Chronic Myeloproliferative Disorders C. Philip Steuber The chronic myeloproliferative disorders in children are rare conditions accounting for 1% to 2% of all childhood malignancies and 3% to 5% of all…
Acute Myeloid Leukemia
Acute Myeloid Leukemia Gladstone E. Airewele C. Philip Steuber EPIDEMIOLOGY Acute myeloid leukemia (AML) represents approximately 20% of all leukemia diagnosed in children. In the United States, about 500 new…
