Chapter 11 Apoptosis, Necrosis, and Autophagy Keith B. Elkon Definitions Apoptosis The modern understanding of apoptosis began with the electron-microscopic descriptions of morphologic changes characterized by shrinkage of hepatocytes (i.e.,…
Chapter 15 Mechanisms of Acute Inflammation and Vascular Injury in SLE J. Michelle Kahlenberg, Mariana J. Kaplan Inflammation and injury of blood vessels in systemic lupus erythematosus (SLE) has been…
Chapter 19 Immune Tolerance Defects in Lupus Ram Raj Singh, Shweta Dubey, Julia Pinkhasov The presence of autoantibodies against a variety of ubiquitous self-antigens is a hallmark of systemic lupus…
Chapter 45 SLE and Infections Judith A. James, Andrea L. Sestak, Evan S. Vista Infections in systemic lupus erythematosus (SLE) remain a significant source of morbidity and mortality. Both the…
Chapter 47 Principles of Therapy, Local Measures, and Nonsteroidal Medications Mariko Ishimori, Michael H. Weisman, Katy Setoodeh, Daniel J. Wallace Formulation Overview One of the most difficult and misunderstood aspects…
Chapter 38 Reproductive and Hormonal Issues in Women with Autoimmune Diseases Eliza F. Chakravarty Introduction Because systemic lupus erythematosus (SLE) commonly affects women during the childbearing years, reproductive issues are…
Chapter 5 Epigenetics of Lupus Nan Shen, Dong Liang, Yuajia Tang, Yuting Qin For a long time, genetic variation has been thought to be the primary cause of systemic lupus…
Chapter 52 Adjunctive and Preventive Measures Diane L. Kamen An improved ability to diagnose and treat systemic lupus erythematosus (SLE) has contributed to longer survival for patients and an increased…
Chapter 20 Autoantibodies PART AAntibody Structure, Function, and Production Jessica Manson Under normal circumstances, the immune system is involved in host defense. A loss of self-tolerance leads to the development…
Chapter 33 Gastrointestinal and Hepatic Manifestations David S. Hallegua, Swamy Venuturupalli Gastrointestinal Involvement Gastrointestinal (GI) manifestations are common in patients with systemic lupus erythematosus (SLE), and the prevalence of their…
