Endocrine abnormalities Cushing’s syndrome, hyperthyroidism, hypogonadism hyperparathyroidism, hypercalciuria, hyperprolactinemia, Panhypopituitarism, diabetes, androgen insensitivity Hematological disorders Multiple myeloma, leukemia, lymphoma, systemic mastocytosis, hemophilia, thalassemia, monoclonal gammopathies Rheumatologic Rheumatoid arthritis, systemic lupus…
Axial SpA Peripheral SpA Back pain ≥3 months Age of onset <45 years Peripheral arthritis and/or enthesitis and/or dactylitis and either column below Sacroiliitis on imaging (Acute inflammation on MRI OR definite…
Classification Clinical features Gene/chromosome/OMIM Protein Inheritance Monogenic periodic fevers Familial Mediterranean fever (FMF) Recurrent febrile episodes with serositis and arthritis. Long-term development of AA amyloidosis in untreated patients. Good clinical…
!DOCTYPE html> © Springer Nature Switzerland AG 2020P. Efthimiou (ed.)Absolute Rheumatology Reviewhttps://doi.org/10.1007/978-3-030-23022-7_17 17. Pediatric Rheumatology for Adult Rheumatologists Natalie Rosenwasser1 and Karen Onel2 (1) University of Washington, Seattle, SA, USA (2) Hospital for Special Surgery,…
Fig. 12.1 Giant cell arteritis. The wall of this muscular artery is diffusely involved by granulomatous inflammation, including scattered multinucleated giant cells, with significant loss of the muscular media and…
Cell Pathogenic effects Fibroblasts Produce collagen and other extracellular matrix molecules Adipocytes, endothelial cells, epithelial cells Undergo transition to myofibroblasts expressing a smooth actin and producing collagen T cells Are…
Fig. 3.1 OA pathophysiology. The pathophysiology of OA involves a variety of systemic and local factors, including trauma, aging, obesity, epigenetic, and genetic factors. Chronic inflammation plays a strong role,…
