General Considerations of Allergies in Childhood Hugh A. Sampson Peyton A. Eggleston The prevalence of allergic disorders such as asthma, atopic dermatitis, and allergic rhinitis has doubled in the past…
Unclassified Nervous System Disorders: Alpers Disease Marvin A. Fishman The term Alpers disease (progressive poliodystrophy) traditionally has been used to refer to a progressive degenerative disease that begins in early…
Phakomatoses and Other Neurocutaneous Syndromes Sharon E. Plon NEUROFIBROMATOSIS Neurofibromatosis (NF) is the term used for a set of distinct disorders that share some clinical characteristics, with NF types 1…
Diseases with Astrocyte Abnormalities Marvin A. Fishman ALEXANDER DISEASE Alexander disease is a degenerative disorder of the nervous system caused by a mutation in the gene encoding glial fibrillary acidic…
Basal Ganglia and Neurotransmitter Disorders Joseph Jankovic Biochemical or structural pathology in the basal ganglia may be manifested by movement disorders, groups of neurologic diseases, or syndromes that are characterized…
Rett Syndrome Alan K. Percy Rett syndrome is a pervasive developmental disorder affecting predominantly females. After a period of apparently normal development, affected children experience a plateau in development and…
Leukodystrophies Alan K. Percy The leukodystrophies are a group of progressive inherited neurodegenerative disorders affecting myelin formation in the central and (in some instances) peripheral nervous systems. As such, they…
Metabolic Encephalopathies Edward R. B. McCabe Many of the metabolic disorders include among their clinical features abnormalities of the central nervous system (CNS). A significant portion of these disorders can…
Slow Virus Infections and Transmissible Spongiform Encephalopathies of the Central Nervous System William J. Britt Transmissible central nervous system (CNS) diseases with unusually long incubation periods and prolonged clinical syndromes…
