Genomic Influences on Hyperuricemia and Gout
Genome-wide association studies (GWAS) have identified nearly 30 loci associated with urate concentrations that also influence the subsequent risk of gout. The ABCG2 Q141 K variant is highly likely to be…
Precision Medicine in Rheumatoid Arthritis
Treatment of rheumatoid arthritis (RA) has substantially improved in recent years because of the development of novel drugs. However, response is not universal for any of the treatment options, and…
Human Leukocyte Antigen–Disease Associations in Rheumatoid Arthritis
The cause and pathogenesis of rheumatoid arthritis (RA) are influenced by environmental and genetic risk factors. Shared epitope-coding human leukocyte antigen (HLA)-DRB1 alleles increase RA risk and severity; however, the…
Genomic Influences on Susceptibility and Severity of Rheumatoid Arthritis
Genetics in rheumatoid arthritis (RA) has moved from the finding of HLA-shared epitope decades ago toward the understanding of the role of HLA in RA and the findings of ∼100…
Genomics, Biology, and Human Illness
The monogenic autoinflammatory diseases are a group of illnesses with prominent rheumatic manifestations that are characterized by genetically determined recurrent sterile inflammation and are thus inborn errors of innate immunity….
Population Genetics and Natural Selection in Rheumatic Disease
Human genetic diversity is the result of population genetic forces. This genetic variation influences disease risk and contributes to health disparities. Natural selection is an important influence on human genetic…
Genomics in Rheumatic Diseases
Michael H. Weisman, MD, Consulting Editor The current issue is one of a kind, bringing together basic, clinical, translational, and computational scientists into one space to address the role of…
Genomics in Rheumatic Diseases: Hope for the Future
S. Louis Bridges, Jr., MD, PhD, Editor Carl D. Langefeld, PhD, Editor The more I learn, the more I realize how much I don’t know. This quote, attributed to Albert…
Genomics in Rheumatic Diseases
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA www.rheumatic.theclinics.com Consulting Editor MICHAEL H. WEISMAN August 2017 • Volume 43 • Number 3
Outlook for Tissue Engineering Strategies for Anterior Cruciate Ligament Reconstruction
Abstract Looking towards the future, there is great interest in developing tissue engineered ACL replacements that have the potential to mimic the native ACL in terms of both biological and…
