Musculoskeletal Key

Fig. 18.1 Avascular necrosis of the left hip in a patient with sickle cell disease (Reprinted with permission from Springer [2]) Acromegaly is characterized by hypersecretion of growth hormone (GH) and…

Fig. 10.1 A model of potential contribution of different factors in SS pathogenesis Table 10.1 Association of non-MHC class genes with SS susceptibility according to distinct pathogenetic pathways   Type I…

2010 ACR/EULAR classification criteria for RA Joint involvement 1 medium/large joint 2–10 medium joints 1–3 small joints 4–10 small joints >10 joints 0–5 points 0 1 2 3 5 Serology…

Pathogenetic concept Consequences Autoimmunity Mucosal initiation Self-protein modifications Ag presentation by the SE Ab production Citrullination of self-proteins in the lung generates neoepitopes, which are presented by the shared epitope…

   Points Clinical   Pattern of joint or bursa involvement during past or present symptomatic episodes Ankle or midfoot without first MTP joint 1 First MTP joint involved 2 Number of…

American College of Rheumatology revised SLE classification criteria Systemic Lupus International Collaborating Clinics (SLICC) criteria Classification as SLE requires 4 out of 11 criteria Classification as SLE requires either 4…

Monogenic periodic fever syndromes  FMF (familial Mediterranean fever)  MKD (mevalonate kinase deficiency)  NLRP3-AID (NLRP3-associated autoinflammatory disease)  TRAPS (TNF receptor-associated periodic fever syndrome)  NLRP12-AID (NLRP12-associated autoinflammatory disease) NOD2-associated diseases  Blau syndrome…

Endocrine abnormalities Cushing’s syndrome, hyperthyroidism, hypogonadism hyperparathyroidism, hypercalciuria, hyperprolactinemia, Panhypopituitarism, diabetes, androgen insensitivity Hematological disorders Multiple myeloma, leukemia, lymphoma, systemic mastocytosis, hemophilia, thalassemia, monoclonal gammopathies Rheumatologic Rheumatoid arthritis, systemic lupus…

Axial SpA Peripheral SpA Back pain ≥3 months Age of onset <45 years Peripheral arthritis and/or enthesitis and/or dactylitis and either column below Sacroiliitis on imaging (Acute inflammation on MRI OR definite…

Classification Clinical features Gene/chromosome/OMIM Protein Inheritance Monogenic periodic fevers Familial Mediterranean fever (FMF) Recurrent febrile episodes with serositis and arthritis. Long-term development of AA amyloidosis in untreated patients. Good clinical…