Musculoskeletal Key

Chapter 18 Genes and Genetics of Murine Lupus Shozo Izui, MD INTRODUCTION Systemic lupus erythematosus (SLE) is a disorder of systemic autoimmunity characterized by the formation of a variety of…

Chapter 21 Immune Complexes in Systemic Lupus Erythematosus Mark H. Wener, MD INTRODUCTION Antigen-antibody complexes mediate much of the inflammation and tissue dysfunction associated with SLE. Deposition of ICs within…

Chapter 16 Autoantibodies in Systemic Lupus Erythematosus David Isenberg, MD , Matthew Adler, MRCP INTRODUCTION Overview of Autoantibodies in SLE One of the hallmarks of systemic lupus erythematosus (SLE) is…

Chapter 20 Role of Complement in Systemic Lupus Erythematosus Pathogenesis Chau-Ching Liu, MD, PhD , Jeannine S. Navratil, MS , Amy H. Kao, MD, MPH , Susan Manzi, MD, MPH…

Chapter 19 Complement Deficiencies in Human Systemic Lupus Erythematosus (SLE) and SLE Nephritis: Epidemiology and Pathogenesis C. Yung Yu, Dphil , Georges Hauptmann, MD, PhD , Yan Yang, MD, PhD…

Chapter 13 Biology of Dendritic Cells Virginia Pascual, MD , A. Karolina Palucka, MD , Jacques Banchereau, MD INTRODUCTION The primary role of the immune system is to protect the…

Chapter 22A Antibodies to DNA David S. Pisetsky, MD, PhD INTRODUCTION Antibodies to DNA (anti-DNA) are prototypic autoantibodies that are the serologic hallmark of systemic lupus erythematosus (SLE). These antibodies…

Chapter 4 Quality of Life and Economic Aspects Ann E. Clarke, MD, MSc , Pantelis Panopalis, MD INTRODUCTION Systemic lupus erythematosus (SLE) primarily affects young women in the prime of…

Chapter 9 Hormonal Influences in the Expression of Systemic Lupus Erythematosus Virginia Rider, PhD , Xiaolan Li, MD , Nabih I. Abdou, MD INTRODUCTION The ability of the immune system…

Chapter 14 Apoptosis Erika Darrah, BS , Antony Rosen, MD INTRODUCTION Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by a wide array of clinical manifestations involving multiple…