Systemic Lupus Erythematosus and Vasculitis
Chapter 27 Systemic Lupus Erythematosus and Vasculitis Tsutomu Takeuchi, MD INTRODUCTION Vasculitis is defined as the inflammation and necrosis of vessel walls as a primary process or as a complication…
The Nervous System in Systemic Lupus Erythematosus
Chapter 37 The Nervous System in Systemic Lupus Erythematosus John G. Hanly, MD INTRODUCTION Although neurological (N) and psychiatric (P) events are frequently encountered in patients with systemic lupus erythematosus…
Cytotoxic Drug Treatment
Chapter 46 Cytotoxic Drug Treatment Eva D. Papadimitraki, MD , Dimitrios T. Boumpas, MD, FACP INTRODUCTION Cytotoxic agents were initially introduced for their ability to interrupt nucleic acid and protein…
Gastrointestinal Disease in Systemic Lupus Erythematosus
Chapter 34 Gastrointestinal Disease in Systemic Lupus Erythematosus Chi Chiu Mok, MD, FRCP INTRODUCTION Gastrointestinal (GI) manifestations of systemic lupus erythematosus (SLE) are protean. Any part of the GI tract,…
New Treatments in Systemic Lupus Erythematosus
Chapter 48 New Treatments in Systemic Lupus Erythematosus Vasileios C. Kyttaris, MD , George C. Tsokos, MD INTRODUCTION Immunosuppressive therapy, the main treatment modality for severe lupus, has been effective…
Systemic Steroids
Chapter 45 Systemic Steroids Mustafa Al-Maini, MD , Murray Urowitz, MD INTRODUCTION Corticosteroid medications are found in the therapeutic armamentarium of most medical specialties. Rheumatologists have had a long relationship…
Overlap Syndromes, Mixed Connective Tissue Disease, and Undifferentiated Connective Tissue Disease
Chapter 38 Overlap Syndromes, Mixed Connective Tissue Disease, and Undifferentiated Connective Tissue Disease Robert W. Hoffman, DO INTRODUCTION Classification of the rheumatic diseases continues to be challenging for a number…
Neonatal Lupus: Clinical Perspectives
Chapter 42 Neonatal Lupus: Clinical Perspectives Anca D. Askanase, MD, MPH , Jill P. Buyon, MD INTRODUCTION Neonatal lupus (NL) is a model of passive autoimmunity; anti-SSA/Ro-SSB/La antibodies (Ab) cross…
Antibodies to SSA/Ro and SSB/La: Potential Mechanisms of Tissue Injury in Neonatal Lupus-Congenital Heart Block
Chapter 22D Antibodies to SSA/Ro and SSB/La: Potential Mechanisms of Tissue Injury in Neonatal Lupus-Congenital Heart Block Jill P. Buyon, MD , Robert M. Clancy, PhD PATHOGENESIS: LAYING THE GROUNDWORK…
