Is Preclinical Autoimmunity Benign?

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Is Preclinical Autoimmunity Benign?

Although there are many examples of autoantibodies in disease-free individuals, they can be a preclinical phenomenon heralding future autoimmune rheumatic disease. They may be a marker for autoreactive B-cell activation…

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Genetics, Environment, and Gene-Environment Interactions in the Development of Systemic Rheumatic Diseases

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Genetics, Environment, and Gene-Environment Interactions in the Development of Systemic Rheumatic Diseases

Rheumatic diseases offer distinct challenges to researchers because of heterogeneity in disease phenotypes, low disease incidence, and geographic variation in genetic and environmental factors. Emerging research areas, including epigenetics, metabolomics,…

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Preclinical Systemic Lupus Erythematosus

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Preclinical Systemic Lupus Erythematosus

Preclinical lupus encompasses a spectrum from enhanced SLE risk without clinical symptoms to individuals with autoantibodies and some SLE clinical features without meeting ACR classification. Studies have identified antibody and…

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Gout

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Gout

Gout is a common inflammatory arthritis triggered by the crystallization of uric acid within the joints. Gout affects millions worldwide and has an increasing prevalence. Recent research has been carried…

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Preclinical Inflammatory Rheumatic Diseases

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Preclinical Inflammatory Rheumatic Diseases

Chronic inflammatory and autoimmune conditions result from an interplay between genetic and environmental factors culminating in the phenotypes of established disease. The transition from health to established disease is relatively…

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Preclinical Rheumatic Disease

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Preclinical Rheumatic Disease

Vivian P. Bykerk, MD, Editor Karen H. Costenbader, MD, MPH, Editor Kevin Deane, MD, PhD, Editor The ability to intervene at the earliest phases in the pathogenesis of a chronic…

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