Connective Tissue Diseases in Childhood: An Approach to the Diagnosis and Classification

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Connective Tissue Diseases in Childhood: An Approach to the Diagnosis and Classification

1. Lupus disorders  (a) Systemic lupus erythematosus (SLE)  (b) Mixed connective tissue disease (MCTD)  (c) Neonatal lupus erythematosus (NLE)   (i) Cardiac   (ii) Noncardiac  (d) Cutaneous lupus erythematosus   (i) Discoid   (ii)…

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Imaging in Pediatric Rheumatology

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Imaging in Pediatric Rheumatology

Fig. 11.1 X-ray of the left hand showing periarticular soft tissue swelling of the proximal inter-phalangeal joints (arrow) in a case of juvenile idiopathic arthritis (JIA) X-rays however have low…

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Childhood Central Nervous System Vasculitis

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Childhood Central Nervous System Vasculitis

Fig. 40.1 Diagnostic evaluation of a child with suspected inflammatory brain disease. Abbreviations: CVID common variable immunodeficiency, HLH hemophagocytic lymphohistiocytosis, HES hypereosinophilic syndrome, vWF von Willebrand factor antigen, LAC lupus…

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Common Orthopedic Problems in Children

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Common Orthopedic Problems in Children

Fig. 16.1 (a) Jack’s windup test. (b) Arch restoration on passive dorsiflexion of the big toe. (c) Arches reformed on heel rise and heels swing into normal varus Standing on…

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Childhood Sarcoidosis

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Childhood Sarcoidosis

Fig. 46.1 Boggy synovitis of both knees in child with early-onset sarcoidosis Fig. 46.2 Skin rash in a child with sarcoidosis following etanercept treatment Introduction Sarcoidosis is challenging both to…

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Management of Juvenile Idiopathic Arthritis

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Management of Juvenile Idiopathic Arthritis

Name Etanercept Infliximab Adalimumab Chemical content Fully humanized Mouse chimeric Fully humanized Chemical structure P-75 soluble TNF receptor protein fused to human Fc region of human IgG1 Chimeric IgG1 Anti-TNF…

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Clinical Case Vignettes: Arthritis in Children

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Clinical Case Vignettes: Arthritis in Children

Fig. 23.1 Chest X-ray of patient S in case vignette 2 showing bilateral nonhomogenous opacities (arrows) Rheumatological disorders rarely present to emergency. Systemic JIA and systemic lupus erythematosus (SLE) are…

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Undifferentiated Connective Tissue Disease, Mixed Connective Tissue Disease, and Overlap Syndromes in Children

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Undifferentiated Connective Tissue Disease, Mixed Connective Tissue Disease, and Overlap Syndromes in Children

Mixed connective tissue disorder Clinical signs of at least two of the following diseases: 1. Juvenile idiopathic arthritis 2. Systemic lupus erythematosus 3. Juvenile dermatomyositis 4. Systemic scleroderma Positive serological findings 1. High titer of…

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