1. Lupus disorders (a) Systemic lupus erythematosus (SLE) (b) Mixed connective tissue disease (MCTD) (c) Neonatal lupus erythematosus (NLE) (i) Cardiac (ii) Noncardiac (d) Cutaneous lupus erythematosus (i) Discoid (ii)…
Fig. 47.1 (a) Two sibs with MONA – note mild coarsening of the face. (b) Painful, claw hand of a child. (c) Radiograph showing osteoporosis, modeling deformities of metacarpals, and…
Fig. 11.1 X-ray of the left hand showing periarticular soft tissue swelling of the proximal inter-phalangeal joints (arrow) in a case of juvenile idiopathic arthritis (JIA) X-rays however have low…
Fig. 40.1 Diagnostic evaluation of a child with suspected inflammatory brain disease. Abbreviations: CVID common variable immunodeficiency, HLH hemophagocytic lymphohistiocytosis, HES hypereosinophilic syndrome, vWF von Willebrand factor antigen, LAC lupus…
Fig. 16.1 (a) Jack’s windup test. (b) Arch restoration on passive dorsiflexion of the big toe. (c) Arches reformed on heel rise and heels swing into normal varus Standing on…
Fig. 46.1 Boggy synovitis of both knees in child with early-onset sarcoidosis Fig. 46.2 Skin rash in a child with sarcoidosis following etanercept treatment Introduction Sarcoidosis is challenging both to…
Name Etanercept Infliximab Adalimumab Chemical content Fully humanized Mouse chimeric Fully humanized Chemical structure P-75 soluble TNF receptor protein fused to human Fc region of human IgG1 Chimeric IgG1 Anti-TNF…
Fig. 45.1 Hypermobility at the 5th metacarpophalangeal joint Fig. 45.2 Hypermobility of the thumb showing the thumb touching the volar aspect of the forearm Fig. 45.3 Hypermobile knee with marked…
Fig. 23.1 Chest X-ray of patient S in case vignette 2 showing bilateral nonhomogenous opacities (arrows) Rheumatological disorders rarely present to emergency. Systemic JIA and systemic lupus erythematosus (SLE) are…
Mixed connective tissue disorder Clinical signs of at least two of the following diseases: 1. Juvenile idiopathic arthritis 2. Systemic lupus erythematosus 3. Juvenile dermatomyositis 4. Systemic scleroderma Positive serological findings 1. High titer of…
