New therapeutic avenues in SLE
Abstract Although the use of corticosteroids and immunosuppressive agents such as cyclophosphamide and mycophenolate has led to reduced mortality in systemic lupus erythematosus (SLE), there is a need for development…
Corrigendum to “Risk of infection with biologic antirheumatic therapies in patients with rheumatoid arthritis” [Best Pract Res Clin Rheumatol 29 (2) (2015) 290–305]
The authors regret that the following sentence on page 300 is inaccurate due to incorrect citations, “There is a suggestion, from the results presented in the primary studies, that the…
Inflammatory myopathies and overlap syndromes: Update on histological and serological profile
Abstract The term ‘inflammatory myopathies’ (IMs) comprise a group of muscle diseases formed by four main categories known as polymyositis (PM), dermatomyositis (DM), inclusion body myositis (IBM) and immune-mediated necrotizing…
New biological therapies in Sjögren’s syndrome
Abstract Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by dryness and systemic involvement in more than a third of the patients. Patient management has suffered from the…
Lipid mediators of inflammation in rheumatoid arthritis and osteoarthritis
Abstract Rheumatoid arthritis (RA) and osteoarthritis (OA) are inflammatory joint diseases, characterized by pain and structural damage. Besides prostaglandins, usually targeted by non-steroidal anti-inflammatory drugs, other lipids, including fatty acids,…
Metabolomics to identify biomarkers and as a predictive tool in inflammatory diseases
Abstract There is an overwhelming need for a simple, reliable tool that aids clinicians in diagnosing, assessing disease activity and treating rheumatic conditions. Identification of biomarkers in partially understood inflammatory…
From mechanisms of action to therapeutic application: A review on current therapeutic approaches and future directions in systemic sclerosis
Abstract Systemic sclerosis (SSc) is one of the most complex connective tissue diseases. Although the pathogenesis of SSc still remains elusive, it is generally accepted that initial vascular injury due…
Refine, reduce, replace: Imaging of fibrosis and arthritis in animal models
Abstract Non-invasive imaging has great potential to contribute to the ‘Three R’s’ principles for more ethical use of experimental animals. It enables repetitive monitoring of disease progression and measurement of…
New immune cells in spondyloarthritis: Key players or innocent bystanders?
Abstract The central role of the inflammatory cytokines such as TNF-α, IL-23, and IL-17 in the disease pathogenesis of spondyloarthritis (SpA) is unquestionable, given the strong efficacy of anti-cytokine therapeutics…
Translating genomics into mechanisms of disease: Osteoarthritis
Abstract Osteoarthritis (OA) is the most common age-related arthritic disorder and is characterized by aberrant extracellular matrix (ECM) content and surface disruptions that range from fibrillation, clefting and delamination, leading…
