Trial Design and Collaborative Work in Pediatric Rheumatology
Fig. 6.1 An example of a trial with withdrawal design. In part I, patients are treated in an open-label fashion with the experimental therapy. In part II, only responders to…
RHEUMATOLOGY
Genetics of Pediatric Rheumatic Diseases
Chr SNP Best p value OR SNP position PTPN22a 1 rs6679677 3.2 × 10−25 1.59 Intergenic ATP8B2-IL6R 1 11265608 2.8 × 10−8 1.33 Intergenic STAT4 2 Rs10174238 1.3 ×…
Epidemiology of Pediatric Rheumatic Diseases
Publication year Reference Authors District Case ascertainment JIA etc. Max (years) Prev. cases Prev per 100,000 Prev 95 % C.I. A.I.* per 100,000 1992 [3] Andersson Gare and Fasth Southwest…
Endothelial Function and its Implications for Cardiovascular and Renal Disease in Systemic Lupus Erythematosus
Vascular manifestations associated with systemic lupus erythematosus (SLE) span a broad range, including vasculopathy. An understudied pathway of this morbidity is a repair component. Recent studies have elevated the anti-injury…
Glutamate Receptor Biology and its Clinical Significance in Neuropsychiatric Systemic Lupus Erythematosus
The recent appreciation that a subset of anti-DNA antibodies cross-reacts with the N -methyl-d-aspartate receptor encourages a renewed examination of antibrain reactivity in systemic lupus erythematosus (SLE) autoantibodies. Moreover, investigations…
Interferon-alpha: A Therapeutic Target in Systemic Lupus Erythematosus
The long history of elevated interferon (IFN)-α in association with disease activity in patients who have systemic lupus erythematosus (SLE) has assumed high significance in the past decade, with accumulating…
Cell-Bound Complement Biomarkers for Systemic Lupus Erythematosus: From Benchtop to Bedside
Systemic lupus erythematosus is arguably the most clinically and serologically diverse autoimmune disease. This article highlights the biomarkers helpful in diagnosing this disease. The authors’ own research is presented. Systemic…
Biomarkers in Lupus Nephritis
Biomarkers have the potential to be useful tools for noninvasively evaluating and managing patients with lupus nephritis. Many candidate biomarkers have been identified, but they require validation in larger cohorts….
B-cell Biology and Related Therapies in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a complex disease characterized by numerous autoantibodies and clinical involvement in multiple organ systems. The immunologic events triggering the onset and progression of clinical manifestations…
Gonadal Failure with Cyclophosphamide Therapy for Lupus Nephritis: Advances in Fertility Preservation
Intravenous cyclophosphamide remains an important therapy for patients with severe systemic lupus erythematosus—including lupus nephritis, which primarily affects women in their reproductive years. As prognosis improves, the chronic toxicity of…
