Gene Therapy
Vectors Capability of transferring genes into nondividing cells Maximum size of insert Stability of transgene expression Retro-/lentiviral vectors No (yes for lentiviral vectors) ≤8 kb Stable (random DNA insertion) Adenoviral…
ORTHOPEDIC
Cell Culture Approaches for Articular Cartilage: Repair and Regeneration
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_13 13. Cell Culture Approaches for Articular Cartilage: Repair and Regeneration Eyitayo S. Fakunle1 and John G. Lane2 (1) Vericel Corporation, 64 Sidney Street, Cambridge, MA 02139, USA (2) Department…
Cell-Free Scaffolds for the Treatment of Chondral and Osteochondral Lesions
Author Study design Scaffold Follow-up period Number of patients Age Gender Site Mean defect size (cm2) Kusano T, KSSTA 2012 [14] Retrospective study Collagen matrix 29 m 38a 26 y…
Orthopedic Sports Disorders: Genetic and Molecular Aspects
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_10 10. Orthopedic Sports Disorders: Genetic and Molecular Aspects Moises Cohen1 , Diego Costa Astur2 and João Victor Novaretti3 (1) Full Professor the Department of Orthopedics and Sports Medicine from Universidade…
Education and Understanding Orthobiologics: Then and Now
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_3 3. Education and Understanding Orthobiologics: Then and Now Steven Sampson1 , Hunter Vincent2 and Mary Ambach3 (1) David Geffen School of Medicine at UCLA, The Orthohealing Center, Los…
Orthobiologics: Regulation in Different Parts of the World
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_4 4. Orthobiologics: Regulation in Different Parts of the World Jason A. Grieshober1, Eyitayo Fakunle2 and Ralph A. Gambardella1 (1) Kerlan-Jobe Orthopaedic Clinic, Los Angeles, CA 90045, USA (2) Vericel Corporation,…
The Optimization of Natural Healing
Fig. 1.1 The phases of tissue healing (https://en.wikipedia.org/wiki/File:Wound_healing_phases.png#References) Altered protease activity is a biomarker of incomplete healing. In the phases of normal wound healing, the production and activity of proteases…
Host Environment: Scaffolds and Signaling (Tissue Engineering) Articular Cartilage Regeneration: Cells, Scaffolds, and Growth Factors
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_7 7. Host Environment: Scaffolds and Signaling (Tissue Engineering) Articular Cartilage Regeneration: Cells, Scaffolds, and Growth Factors Livia Roseti1 and Brunella Grigolo1, 2 (1) RAMSES Laboratory, Rizzoli…
Physiology and Homeostasis of Musculoskeletal Structures, Injury Response, Healing Process, and Regenerative Medicine Approaches
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_6 6. Physiology and Homeostasis of Musculoskeletal Structures, Injury Response, Healing Process, and Regenerative Medicine Approaches Kaitlyn E. Whitney1, Ioanna Bolia1, Jorge Chahla1, Hajime Utsunomiya1, Thos A. Evans1, Matthew Provencher1, Peter J. Millett1, Robert F. LaPrade1, Marc J. Philippon1…
Shoulder Arthroplasty: Evolution in Design, Indications, Surgical Technique, and Associated Complications
Fig. 1 Seebauer classification for rotator cuff arthropathy. (a) Type IA demonstrates a stable-centered humeral head with minimal superior migration, acetabularization of the acromion, and femoralization of the humeral head….
