Arvind von Keudell and Michael J. Weaver Infection after fracture surgery is a challenging entity. Prompt diagnosis and treatment is of paramount importance. Successful treatment includes culture-specific antibiotic therapy…
Malcolm E. Dombrowski and Brian A. Klatt Periprosthetic joint infection (PJI) continues to be a devastating problem in the field of total joint arthroplasty. There are a number of…
Timothy L. Tan and Sommer Hammoud A septic native joint can be a debilitating condition that is associated with significant morbidity and mortality. Traditionally, a septic native joint was…
Patrick Moody and Bryan Springer The postoperative dressing functions as an important barrier to prevent orthopaedic infections and reinfections. Preoperative assessment of patient factors and intraoperative evaluation of the…
Michael Yayac, Samuel J. Clarkson, Craig Della Valle, and Javad Parvizi This chapter will provide an overview of antiseptic agents used to irrigate wounds for the prevention or treatment…
Alaina S. Ritter and Sandra B. Nelson Antibiotics play a critical role in the treatment of bone and joint infections. In clinical practice, antibiotics may be delivered intravenously, orally,…
Michael Henry, Andy O. Miller, and Barry D. Brause A very broad range of microorganisms cause orthopaedic infections. Modern diagnosis depends on traditional culture techniques, which remain in common…
Chapter 1 : History of pediatric critical care medicine 1. Treatment for which of the following disease entities was not an important trigger in the early development of distinct, full-time,…
• The pathophysiology of sickle cell disease is multifactorial, involving hemoglobin polymerization, oxidative damage to cell membrane proteins, white blood cell activation and inflammation, activation of the clotting cascade, and…
Pearls • Receptors play a central role in determining the nature of the pharmacologic effects produced by a drug. • Most drugs and endogenous compounds (e.g., hormones, neurotransmitters) exert their…
