Genomic Influences on Susceptibility and Severity of Rheumatoid Arthritis
Genetics in rheumatoid arthritis (RA) has moved from the finding of HLA-shared epitope decades ago toward the understanding of the role of HLA in RA and the findings of ∼100…
Genomics, Biology, and Human Illness
The monogenic autoinflammatory diseases are a group of illnesses with prominent rheumatic manifestations that are characterized by genetically determined recurrent sterile inflammation and are thus inborn errors of innate immunity….
Population Genetics and Natural Selection in Rheumatic Disease
Human genetic diversity is the result of population genetic forces. This genetic variation influences disease risk and contributes to health disparities. Natural selection is an important influence on human genetic…
Genomics in Rheumatic Diseases
Michael H. Weisman, MD, Consulting Editor The current issue is one of a kind, bringing together basic, clinical, translational, and computational scientists into one space to address the role of…
Genomics in Rheumatic Diseases: Hope for the Future
S. Louis Bridges, Jr., MD, PhD, Editor Carl D. Langefeld, PhD, Editor The more I learn, the more I realize how much I don’t know. This quote, attributed to Albert…
Genomics in Rheumatic Diseases
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA www.rheumatic.theclinics.com Consulting Editor MICHAEL H. WEISMAN August 2017 • Volume 43 • Number 3
Outlook for Tissue Engineering Strategies for Anterior Cruciate Ligament Reconstruction
Abstract Looking towards the future, there is great interest in developing tissue engineered ACL replacements that have the potential to mimic the native ACL in terms of both biological and…
Motion Analysis in Anterior Cruciate Ligament Deficient and Reconstructed Knees
Abstract The objective measurement of knee motion during functional activities with 3D motion analysis has provided great insights into the restoration of knee biomechanics after ACL reconstructions and any remaining…
Extra-Articular Tenodesis and Anterior Cruciate Ligament Reconstruction: Techniques and Outcomes
Introduction Historically, anterior laxity in anterior cruciate ligament (ACL) deficient knees was treated surgically by isolated tenodesis, as described by Lemaire or MacIntosh. This procedure was largely abandoned in favor…
Growth Factors and Other New Methods for Graft-Healing Enhancement
Abstract Modern intra-articular anterior cruciate ligament (ACL) reconstructive techniques produce clinically stable ligament reconstruction in the majority of cases. In ACL reconstruction, however, the strength of the grafted tendon is…
