Patient Reported Outcomes in Rheumatic Diseases
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA www.rheumatic.theclinics.com Consulting Editor MICHAEL H. WEISMAN May 2016 • Volume 42 • Number 2
New Treatment Guidelines for Sjögren’s Disease
Sjögren’s disease is associated with a high burden of illness, diminished quality of life, and increased health care costs. The Sjögren’s Syndrome Foundation developed the first US clinical practice guidelines…
Sjögren Syndrome
Sjögren syndrome (SS) comprises glandular and extraglandular manifestations. Double-blind prospective trials of traditional disease-modifying antirheumatic drugs and biologics have failed because they have not improved benign symptoms, the major cause…
Major Salivary Gland Ultrasonography in the Diagnosis of Sjögren’s Syndrome
Major salivary gland (SG) ultrasonography (US) represents a noninvasive, nonirradiating imaging modality for evaluation of the major SGs in the diagnosis and follow-up of primary and secondary Sjögren syndrome. Structural…
Parotid Gland Biopsy, the Alternative Way to Diagnose Sjögren Syndrome
Salivary gland biopsy is a technique broadly applied for the diagnosis of Sjögren syndrome (SS), lymphoma in SS, and connective tissue disorders (sarcoidosis, amyloidosis). In SS characteristic histology findings are…
Salivary Gland Pathology in Sjögren’s Syndrome
Primary Sjögren syndrome (pSS) can be considered a systemic autoimmune disease with a strong organ bias. The involvement of the exocrine glands is prevalent and drives the pathognomonic manifestations of…
Polyautoimmunity in Sjögren Syndrome
Polyautoimmunity is defined as the presence of more than one well-defined autoimmune disease (AD) in a single patient. Polyautoimmunity is a frequent condition in Sjögren syndrome (SS) and follows a…
The Proteomics of Saliva in Sjögren’s Syndrome
One of the main characteristics of primary Sjögren’s syndrome (pSS) is chronic dysfunction and destruction of the salivary and lacrimal glands; their secretory biofluids should reflect the glandular biological status….
Genetics in Sjögren Syndrome
The genes associated with Sjögren syndrome (SS) can be assigned to the NF-kB pathway, the IFN signaling pathway, lymphocyte signaling, and antigen presentation. The frequencies of risk variants show they…
Autoantibodies in Sjögren’s Syndrome
We compiled information on antibodies in Sjögren syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as…
