The Kidney Biopsy in Lupus Nephritis
The kidney biopsy is the standard of care for diagnosis of lupus nephritis and remains necessary to ensure accurate diagnosis and guide treatment. Repeat biopsy should be considered when therapy…
Recent Clinical Trials in Lupus Nephritis
Recent clinical trials have provided evidence for the efficacy of low-dose intravenous cyclophosphamide and mycophenolate mofetil as induction treatment for patients with proliferative lupus nephritis in comparative trials with standard-dose…
Post-marketing Experiences with Belimumab in the Treatment of SLE Patients
Belimumab (Benlysta) is a human recombinant monoclonal antibody that targets and inhibits soluble B-lymphocyte stimulator, also known as B-cell activating factor, a proliferation and survival factor for B cells. The…
Systemic Lupus Erythematosus and Malignancies
The systemic lupus erythematosus (SLE) population has a unique cancer risk profile. This article presents the most recent data on risk of cancer in lupus and discusses possible contributing factors….
Pathogenesis and Treatment of Atherosclerosis in Lupus
The prevalence of atherosclerosis (ATH) is higher in patients with systemic lupus erythematosus (SLE) and occurs at an earlier age. The lupus-related factors that account for this increased risk are…
Impact of Race and Ethnicity in the Course and Outcome of Systemic Lupus Erythematosus
Genetic factors seem to play a more important role early in the course of systemic lupus erythematosus (SLE), whereas nongenetic factors seem to play a more important role over the…
The Immunopathology of Cutaneous Lupus Erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the development of autoantibodies and immunologic attack of different organ systems, including the skin. This review aims to…
Clinical Perspectives on Lupus Genetics
In recent years, genome-wide association studies have led to an expansion in the identification of regions containing confirmed genetic risk variants within complex human diseases, such as systemic lupus erythematosus…
Environmental Influences on Systemic Lupus Erythematosus Expression
The etiology of systemic lupus erythematosus (SLE) is unknown, but multiple genetic, epigenetic, and environmental risk factors have been implicated. The inheritance of genes alone is not sufficient for developing…
Systemic Lupus Erythematosus
Ellen M. Ginzler, MD, MPH, Editor Mary Anne Dooley, MD, MPH, Editor The last issue of Rheumatic Disease Clinics of North America to cover systemic lupus erythematosus (SLE) was published…
