SLE in Childhood and Adolescence
Chapter 40 SLE in Childhood and Adolescence Thomas J.A. Lehman Children and adolescents with systemic lupus erythematosus (SLE) represent both a special challenge and a special opportunity. Early onset allows…
Novel Therapies for SLE: Biological Agents Available in Practice Today
Chapter 53 Novel Therapies for SLE Biological Agents Available in Practice Today Ronald F. van Vollenhoven Introduction Only a very few medications are specifically approved by regulatory agencies for the…
Apoptosis, Necrosis, and Autophagy
Chapter 11 Apoptosis, Necrosis, and Autophagy Keith B. Elkon Definitions Apoptosis The modern understanding of apoptosis began with the electron-microscopic descriptions of morphologic changes characterized by shrinkage of hepatocytes (i.e.,…
Mechanisms of Acute Inflammation and Vascular Injury in SLE
Chapter 15 Mechanisms of Acute Inflammation and Vascular Injury in SLE J. Michelle Kahlenberg, Mariana J. Kaplan Inflammation and injury of blood vessels in systemic lupus erythematosus (SLE) has been…
Immune Tolerance Defects in Lupus
Chapter 19 Immune Tolerance Defects in Lupus Ram Raj Singh, Shweta Dubey, Julia Pinkhasov The presence of autoantibodies against a variety of ubiquitous self-antigens is a hallmark of systemic lupus…
SLE and Infections
Chapter 45 SLE and Infections Judith A. James, Andrea L. Sestak, Evan S. Vista Infections in systemic lupus erythematosus (SLE) remain a significant source of morbidity and mortality. Both the…
Principles of Therapy, Local Measures, and Nonsteroidal Medications
Chapter 47 Principles of Therapy, Local Measures, and Nonsteroidal Medications Mariko Ishimori, Michael H. Weisman, Katy Setoodeh, Daniel J. Wallace Formulation Overview One of the most difficult and misunderstood aspects…
Reproductive and Hormonal Issues in Women with Autoimmune Diseases
Chapter 38 Reproductive and Hormonal Issues in Women with Autoimmune Diseases Eliza F. Chakravarty Introduction Because systemic lupus erythematosus (SLE) commonly affects women during the childbearing years, reproductive issues are…
Epigenetics of Lupus
Chapter 5 Epigenetics of Lupus Nan Shen, Dong Liang, Yuajia Tang, Yuting Qin For a long time, genetic variation has been thought to be the primary cause of systemic lupus…
Adjunctive and Preventive Measures
Chapter 52 Adjunctive and Preventive Measures Diane L. Kamen An improved ability to diagnose and treat systemic lupus erythematosus (SLE) has contributed to longer survival for patients and an increased…
