Translational Research in Nucleic Acid Therapies for Muscular Dystrophies
Fig. 6.1 Mechanism of exon skipping therapy in DMD and DYSF. The deletion of exon 52 in the DMD gene results in an out-of-frame transcript that does not produce functional…
Fukuyama Congenital Muscular Dystrophy: Clinical Aspects
Fig. 1.1 Facial appearance changes with age in a girl with FCMD; images were obtained at 7 months (A), at 1 year and 5 months (B), and at 8 years…
Targeting the Type I TGF-β Receptor for Treating Caveolin-3-Deficient Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1C and Muscle Wasting Disorders
Fig. 5.1 Caveolins regulate myostatin and related TGF-β signaling at the type I receptor level. (a) Schematic representation of myostatin and related TGF-β signaling and caveolin-3. Type I serine/threonine receptor…
Toward Regenerative Medicine for Muscular Dystrophies
© Springer Japan 2016Shin’ichi Takeda, Yuko Miyagoe-Suzuki and Madoka Mori-Yoshimura (eds.)Translational Research in Muscular Dystrophy10.1007/978-4-431-55678-7_7 7. Toward Regenerative Medicine for Muscular Dystrophies Lessons from Regeneration Processes Akiyoshi Uezumi1 and So-ichiro Fukada2 (1) Division for Therapies Against Intractable Diseases,…
Combined PCL, Posteromedial Corner, and Posterolateral Corner Reconstruction
Fig. 18.1 Illustration depicting the anatomy of the posteromedial structures of the knee. (From [43]. Reprinted with permission from Thieme Publishers) For the initial posteromedial approach to the knee, the…
Revision Surgery in Posterior Cruciate Ligament Reconstruction
Iatrogenic Untreated combined instabilities Missed posterolateral corner injury Nonanatomic tunnel placement Incorrect graft tensioning/inadequate fixation Untreated or unrecognized meniscal or articular pathology Biologic Failure of graft incorporation (especially with allograft)…
MRI of PCL, Posteromedial, and Posterolateral Corner Injuries of the Knee
Fig. 6.1 X-ray showing posterior displacement of the tibia on the femur. The radiographic posterior drawer is indicative of PCL tear. PCL posterior cruciate ligament Fig. 6.2 a and b…
Surgical Treatment of Combined PCL/Lateral-Sided Injuries
Fig. 16.1 A view of the right knee joint from above after removal of the right femur. Note the three layers of the lateral side and the division of the…
Combined PCL, ACL, Posteromedial, and Posterolateral Reconstruction
(1) 303 Kaseville Road, 17821 Danville, PA, USA KeywordsMultiple ligament knee injuryMechanical graft tensionerAllograftTranstibial PCL reconstructionInside-to-outside PCL femoral tunnels Introduction The multiple-ligament-injured knee is a severe injury that may also…
Anatomy and Biomechanics of the Posterolateral and Posteromedial Corners of the Knee and Their Surgical Implications
(1) Department of BioMedical Engineering, Steadman Philippon Research Institute, 181 W. Meadow Dr., Suite 1000, 81657 Vail, CO, USA Evan W. James Email: drlaprade@sprivail.org KeywordsPosterolateral cornerPosteromedial cornerFibular collateral ligamentPopliteus tendonPopliteofibular…
