Parameters that are commonly extracted from studies Characteristics of the manuscript Author Publication year Study duration Study design Factors related to risk of bias Participant characteristics Number Age Sex Diagnosis/criteria…
, with is the α/2 quantile of a t-distribution with 2n − 2 degrees of freedom. These steps illustrate a few important things for computing the sample size: Clinicians must have a…
Fig. 1 Types of biomarkers that can be used at different stages of rheumatoid arthritis The majority of biomarkers in RA are also molecular like autoantibodies, cytokines, and acute-phase reactants….
, Yusuf Yazici2 and Emmanuel Lesaffre3, 4 (1) Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey (2) Division of Rheumatology, NYU Hospital for Joint Diseases, New…
, Emmanuel Lesaffre2, 3 and Yusuf Yazici4 (1) Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey (2) Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (3)…
RCTs Observational studies Strengths Randomization Large sample sizes and greater statistical power Blinding Greater external validity (more representative population) Limitations External validity is limited (usually highly selected population) Case…
© Springer International Publishing Switzerland 2014Hasan Yazici, Yusuf Yazici and Emmanuel Lesaffre (eds.)Understanding Evidence-Based Rheumatology10.1007/978-3-319-08374-2_3 Disease Classification/Diagnosis Criteria Hasan Yazici1 and Yusuf Yazici2 (1) Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, Cerrahpasa Hospital, University of…
Fig. 1 Radiographic outcomes in randomized controlled trials with methotrexate-naïve patients. TNF tumor necrosis factor inhibitor, MTX methotrexate, ETA etanercept, IFX infliximab, ADA adalimumab, ERA early rheumatoid arthritis (From Yazici…
Fig. 1 Algorithm for setting up a rheumatology research project Create a Multidisciplinary Study Team (i.e., Clinicians, Epidemiologists, Biostatisticians, Ethicists, Patient Representatives, and Others, as Needed) Any rheumatology research is…
and Hasan Yazici2 (1) Division of Rheumatology, Rush University Medical Center, 1611 West Harrison Street, Chicago, IL 60612, USA (2) Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul,…
