Closed Joint ACL Disruption Murine Model of PTA
Fig. 7.1 Left: Setup to initiate ACL rupture injuries, consisting of custom platens designed to hold the knee and ankle joints, a load cell, and a tube for administering anesthesia,…
Animal Models of Meniscal Injury in Post-Traumatic Arthritis
Fig. 5.1 (a) Illustration of anatomy of meniscus orientation on the tibial plateau in the human left knee. (Reproduced from Makris et al. The knee meniscus: Structure-function, pathophysiology, current repair…
Outcomes of ACL Injury: The MOON Consortium
Baseline 2-year Difference IKDC 53 (40, 65) 84 (74, 92) +31 KOOS ADL 88 (72, 97) 98.5 (92.6, 100) +10.5 KOOS QoL 38 (19, 50) 75 (62, 88) +37…
Potential Mechanisms of PTA: Cell Death
Fig. 15.1 Overview of cell death-related pathways. Extrinsic apoptosis involving death receptors and extracellular ligands leads to the activation of caspases. Inhibition of caspases is mediated by various molecules including…
Arthritis After Joint Injury: The Military Experience
Fig. 3.1 Prior to and during OIF/OND and OEF, frequencies of medical discharge due to osteoarthritis have stayed nearly the same. However, back, upper, and lower extremity conditions have resulted…
In Vitro Cartilage Explant Injury Models
Fig. 4.1 A load-controlled test apparatus to apply single or cyclic loads to multiple cartilage specimens. (A) Pneumatic air pistons to load the explants. (B) Piston rod with flat-bottom, cylindrical,…
Unanswered Questions and Future Directions in Post-Traumatic Arthritis
© Springer Science+Business Media New York 2015Steven A. Olson, MD and Farshid Guilak, PhD (eds.)Post-Traumatic Arthritis10.1007/978-1-4899-7606-2_28 28. Unanswered Questions and Future Directions in Post-Traumatic Arthritis Steven A. Olson1 and Farshid Guilak2 (1) Department of Orthopedic Surgery, Duke University…
Stem Cell Therapies for Post-Traumatic Arthritis
Title: A phase I/II, randomized, controlled, double-blind, study of chondrogen—adult universal cell delivered by intra-articular injection following meniscectomy in patients 18–60 years ClinicalTrials.gov Identifier: NCT00225095 Sponsor: Mesoblast International Sàrl Purpose:…
Potential Targets for Pharmacologic Therapies for Prevention of PTA
Drugs Mechanism of action In vitro effect on chondrocytes Pathology used for Effects reported in clinical studies Country performed at Oral vitamin E Antioxidant Improved chondrocyte viability Prevention of knee…
Non-arthroplasty Treatments for PTA in the Lower Extremity
Nonoperative NSAIDs Physical therapy Aquatic therapy Operative Hip arthrodesis PTA Knee: Nonoperative Let us assume for a moment that the treatment of osteoarthritis of the knee can be translated to…
