Genetic Association, and Genomic Studies
Fig. 1 Types of biomarkers that can be used at different stages of rheumatoid arthritis The majority of biomarkers in RA are also molecular like autoantibodies, cytokines, and acute-phase reactants….
Directions
, Yusuf Yazici2 and Emmanuel Lesaffre3, 4 (1) Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey (2) Division of Rheumatology, NYU Hospital for Joint Diseases, New…
Issues in Study Design and Reporting
, Emmanuel Lesaffre2, 3 and Yusuf Yazici4 (1) Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey (2) Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands (3)…
Issues Relevant to Observational Studies, Registries, and Administrative Health Databases in Rheumatology
RCTs Observational studies Strengths Randomization Large sample sizes and greater statistical power Blinding Greater external validity (more representative population) Limitations External validity is limited (usually highly selected population) Case…
Classification/Diagnosis Criteria
© Springer International Publishing Switzerland 2014Hasan Yazici, Yusuf Yazici and Emmanuel Lesaffre (eds.)Understanding Evidence-Based Rheumatology10.1007/978-3-319-08374-2_3 Disease Classification/Diagnosis Criteria Hasan Yazici1 and Yusuf Yazici2 (1) Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, Cerrahpasa Hospital, University of…
Measures in Rheumatoid Arthritis
Fig. 1 Radiographic outcomes in randomized controlled trials with methotrexate-naïve patients. TNF tumor necrosis factor inhibitor, MTX methotrexate, ETA etanercept, IFX infliximab, ADA adalimumab, ERA early rheumatoid arthritis (From Yazici…
in Setting Up a Study and Data Collection
Fig. 1 Algorithm for setting up a rheumatology research project Create a Multidisciplinary Study Team (i.e., Clinicians, Epidemiologists, Biostatisticians, Ethicists, Patient Representatives, and Others, as Needed) Any rheumatology research is…
Medicine in Rheumatology: How Does It Differ from Other Diseases?
and Hasan Yazici2 (1) Division of Rheumatology, Rush University Medical Center, 1611 West Harrison Street, Chicago, IL 60612, USA (2) Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul,…
Imaging Specific to Cartilage Injury
Fig. 19.1 This cut-through demonstrates a tear within the ACL (long arrow) on a 3D SPGR image (left) and a 2D Fast Spin Echo (FSE) T2 weighted image (right). The…
Potential Mechanism of PTA: Alterations in Joint Loading
Fig. 18.1 Contact stress patterns across the surface of the proximal tibia at 14 % of the gait cycle show that load is distributed across both tibial plateaus but varies…
