Title: A phase I/II, randomized, controlled, double-blind, study of chondrogen—adult universal cell delivered by intra-articular injection following meniscectomy in patients 18–60 years ClinicalTrials.gov Identifier: NCT00225095 Sponsor: Mesoblast International Sàrl Purpose:…
Drugs Mechanism of action In vitro effect on chondrocytes Pathology used for Effects reported in clinical studies Country performed at Oral vitamin E Antioxidant Improved chondrocyte viability Prevention of knee…
Nonoperative NSAIDs Physical therapy Aquatic therapy Operative Hip arthrodesis PTA Knee: Nonoperative Let us assume for a moment that the treatment of osteoarthritis of the knee can be translated to…
Positively Negatively Anatomic reduction Posterior wall involvement Congruent joint reduction Articular step-off >2 mm Age <40 years Femoral head involvement/dislocation Age >55–60 years Intra-articular fracture fragmentation Osteonecrosis Fracture displacement >10–20…
© Springer Science+Business Media New York 2015Steven A. Olson, MD and Farshid Guilak, PhD (eds.)Post-Traumatic Arthritis10.1007/978-1-4899-7606-2_16 16. Potential Mechanisms of PTOA: Inflammation Mary B. Goldring1 (1) Research Division, Tissue Engineering, Regeneration and Repair Program, The Hospital for…
Strain ACL-T type Surgery age Exp. time Results Reference Unknown Stab incision Unknown 1–26 weeks OA changes in articular cartilage (fibrillation, loss of cells in superficial layer); synovitis subsides within…
© Springer Science+Business Media New York 2015Steven A. Olson, MD and Farshid Guilak, PhD (eds.)Post-Traumatic Arthritis10.1007/978-1-4899-7606-2_2 2. Post-Traumatic Arthritis: Definitions and Burden of Disease Joseph A. Buckwalter1, 2 and David T. Felson3 (1) Department of Orthopedics and Rehabilitation, University…
Fig. 1.1 A case presentation of a 40-year-old patient who sustains a posterior wall fracture of the acetabulum with subluxation of the femoral head. The patient reported no pre-injury hip…
Fig. 10.1 Summary of outcomes for models of PTA for the mouse, rabbit, and dog. To demonstrate variability in the development of PTA for a small, mid-sized, and large animal…
, James B. Galloway2 and David L. Scott2 (1) Molecular and Cellular Biology of Inflammation, King’s College London, London, UK (2) Rheumatology, King’s College Hospital, London, UK Abstract DMARDs are a diverse range…
