Emerging Biological Approaches to Muscle Injuries
Fig. 19.1 Schematic overview of skeletal muscle structure Skeletal muscle function is controlled by motor neurons that enter the muscle at the motor point. Each individual muscle fiber is contacted…
Stem Cells in Joint Repair
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_17 17. Stem Cells in Joint Repair Celeste Scotti1 , Kota Koizumi2, 3 and Norimasa Nakamura4, 5 (1) Musculoskeletal Translational Medicine, Novartis Institutes for Biomedical Research Basel, Novartis Pharma…
Gene Therapy
Vectors Capability of transferring genes into nondividing cells Maximum size of insert Stability of transgene expression Retro-/lentiviral vectors No (yes for lentiviral vectors) ≤8 kb Stable (random DNA insertion) Adenoviral…
Cell Culture Approaches for Articular Cartilage: Repair and Regeneration
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_13 13. Cell Culture Approaches for Articular Cartilage: Repair and Regeneration Eyitayo S. Fakunle1 and John G. Lane2 (1) Vericel Corporation, 64 Sidney Street, Cambridge, MA 02139, USA (2) Department…
Cell-Free Scaffolds for the Treatment of Chondral and Osteochondral Lesions
Author Study design Scaffold Follow-up period Number of patients Age Gender Site Mean defect size (cm2) Kusano T, KSSTA 2012 [14] Retrospective study Collagen matrix 29 m 38a 26 y…
Orthopedic Sports Disorders: Genetic and Molecular Aspects
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_10 10. Orthopedic Sports Disorders: Genetic and Molecular Aspects Moises Cohen1 , Diego Costa Astur2 and João Victor Novaretti3 (1) Full Professor the Department of Orthopedics and Sports Medicine from Universidade…
Orthobiologics: Regulation in Different Parts of the World
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_4 4. Orthobiologics: Regulation in Different Parts of the World Jason A. Grieshober1, Eyitayo Fakunle2 and Ralph A. Gambardella1 (1) Kerlan-Jobe Orthopaedic Clinic, Los Angeles, CA 90045, USA (2) Vericel Corporation,…
Education and Understanding Orthobiologics: Then and Now
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_3 3. Education and Understanding Orthobiologics: Then and Now Steven Sampson1 , Hunter Vincent2 and Mary Ambach3 (1) David Geffen School of Medicine at UCLA, The Orthohealing Center, Los…
The Optimization of Natural Healing
Fig. 1.1 The phases of tissue healing (https://en.wikipedia.org/wiki/File:Wound_healing_phases.png#References) Altered protease activity is a biomarker of incomplete healing. In the phases of normal wound healing, the production and activity of proteases…
Host Environment: Scaffolds and Signaling (Tissue Engineering) Articular Cartilage Regeneration: Cells, Scaffolds, and Growth Factors
© ISAKOS 2017Alberto Gobbi, João Espregueira-Mendes, John G. Lane and Mustafa Karahan (eds.)Bio-orthopaedics10.1007/978-3-662-54181-4_7 7. Host Environment: Scaffolds and Signaling (Tissue Engineering) Articular Cartilage Regeneration: Cells, Scaffolds, and Growth Factors Livia Roseti1 and Brunella Grigolo1, 2 (1) RAMSES Laboratory, Rizzoli…
