Musculoskeletal Key

Fig. 7.1 Number of PubMed entries for sarcopenia and cachexia as respective search words (Assessed on 1 February 2016 from www.​pubmed.​gov) To date, pharmacologic therapies for the treatment of sarcopenia…

Fig. 8.1 Transcriptional and translational control of skeletal muscle PGC-1α. Exercise is a potent regulator of PGC-1α in muscle. Increases in calcium concentration (Ca2+) activate the p-38 mitogen-activated protein kinase…

© Springer Nature Singapore Pte Ltd. 2017Kunihiro Sakuma (ed.)The Plasticity of Skeletal Muscle10.1007/978-981-10-3292-9_13 13. Therapeutic Potential of Skeletal Muscle Plasticity and Slow Muscle Programming for Muscular Dystrophy and Related Muscle Conditions Gordon S. Lynch1   (1) Basic…

© Springer Nature Singapore Pte Ltd. 2017Kunihiro Sakuma (ed.)The Plasticity of Skeletal Muscle10.1007/978-981-10-3292-9_10 10. Biological Role of TRPC1 in Myogenesis, Regeneration, and Disease Ella W. Yeung1  , Kwok-Kuen Cheung1 and Keng-Ting Sun1 (1) Muscle Physiology Laboratory, Department of Rehabilitation…

Fig. 2.1 Schematic diagram of the 26S proteasome. The 26S proteasome consists of the 20S core particle (CP) and the 19S regulatory particle (RP). The CP is made up of…

Fig. 9.1 Skeletal muscle is a secreted organ. Several proteins and low molecular weight peptides are secreted by muscle cells. These secreted factors can regulate muscle itself in addition to…

Cell type Source Anatomic localisation Molecular markers Myogenic differentiation Model Systemic delivery References SCs (myoblasts) Skeletal muscle Between basal lamina and sarcolemma of muscle fibres Pax7, MyoD, M-cadherin, CD56, desmin…

Fig. 5.1 Humoral mediators and associated pathways drive anabolic and catabolic responses in the skeletal muscle (Costamagna et al. [40]) 5.3 Muscle Injury and Immune Cells Even though molecular regulation…